长新冠综合征与肌少症关系的研究进展  

Research progress of relationship in long-novel coronavirus syndrome and sarcopenia

作　　者：钟文[1] 贾华楠[1] 刘传凤 黄伟 杜坚 陈梦君[1] Zhong Wen;Jia Hua'nan;Liu Chuanfeng;Huang Wei;Du Jian;Chen Mengjun(Department of Geriatrics,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,Sichuan,China;Department of Geriatrics,Hanyuan County Hospital of Traditional Chinese Medicine,Hanyuan 625302,Sichuan,China)

机构地区：[1]成都中医药大学附属医院老年病科,四川成都610072 [2]汉源县中医医院老年病科,四川汉源625302

出　　处：《中华危重病急救医学》2024年第1期106-109,共4页Chinese Critical Care Medicine

基　　金：国家自然科学基金(81804157);四川省干部保健委员会普及应用项目(2023-503);四川省科技厅科技创新基地(平台)和人才计划项目(2022JDKP0077)。

摘　　要：目前新型冠状病毒(新冠病毒)感染带来的重大公共卫生挑战已经逐渐平息,然而,仍有大量人群受到长新冠综合征或后新冠综合征的困扰。长新冠综合征的临床表现为新冠病毒感染后累及呼吸、循环、神经、消化及运动等多个系统的长期持续症状。同时,新冠病毒感染是导致老年人群发生衰弱、肌少症的重要原因。然而,目前临床及学术界对新冠病毒感染导致的骨骼肌衰减尚未充分重视。因此,本文围绕长新冠综合征与肌少症的关系展开综述,探寻新冠病毒介导"细胞因子风暴"、线粒体损害、低氧状态等多个环节导致骨骼肌衰减的病理机制,旨在提高临床及学术界的重视,共同完善新冠病毒感染后衰弱和肌少症的临床应对策略。At present,the major public health challenges caused by novel coronavirus infection have gradually subside.However,a large number of people are still suffering from long-novel coronavirus syndrome or post-novel coronavirus syndrome.The clinical manifestations of long coronavirus syndrome are related to multiple systems,such as respiratory,circulatory,nervous,digestive and musculoskeletal systems,with various long-term persistent symptoms after novel coronavirus infection.At the same time,the infection of the novel coronavirus is an important cause of frailty and sarcopenia in the elderly population.However,at present,the scholars have not paid enough attention to the skeletal muscle weakness caused by the novel coronavirus.Therefore,this paper focuses on the long-novel coronavirus syndrome and sarcopenia to explore the pathological mechanism of skeletal muscle attenuation caused by the SARS-CoV-2 mediated"cytokine storm",mitochondrial damage,hypoxia state and other links,so as to raise the attention of clinical and academic researchers and improve the clinical strategy of frailty and sarcopenia after novel coronavirus infection.

关 键 词：长新冠综合征 肌少症 衰弱 肌量 肌力 后新冠综合征 

分 类 号：R563.1[医药卫生—呼吸系统] R685[医药卫生—内科学]