老年高血压患者载脂蛋白A-Ⅰ与颈动脉粥样硬化的相关性分析  

Correlation analysis between apolipoprotein A-Ⅰand carotid atherosclerosis in elderly patients with hypertension

作　　者：李利香[1] 郭晋文[2] 李春蕾[3] 任杰[1] 杨国东[4] 王晶[1] 赵国磊 沈剑虹[1] LI Lixiang;GUO Jinwen;LI Chunlei;REN Jie;YANG Guodong;WANG Jing;ZHAO Guolei;SHEN Jianhong(Department of Cardiology,The First Hospital of Hohhot,Hohhot 010030,China.;Department of Geriatrics,The First Hospital of Hohhot,Hohhot 010030,China.;Department of Ultrasound Medicine,The First Hospital of Hohhot,Hohhot 010030,China.;Department of Medical Laboratory,The First Hospital of Hohhot,Hohhot 010030,China.)

机构地区：[1]呼和浩特市第一医院心血管内科,010030 [2]呼和浩特市第一医院老年医学一科,010030 [3]呼和浩特市第一医院超声医学科,010030 [4]呼和浩特市第一医院医学检验科,010030

出　　处：《中国老年保健医学》2024年第1期62-65,69,共5页Chinese Journal of Geriatric Care

基　　金：呼和浩特市第一医院院级科研项目(编号:2022SYY005)。

摘　　要：目的探讨老年高血压患者载脂蛋白A-Ⅰ与颈动脉粥样硬化的相关性,为老年高血压患者的危险因素进行早期干预提供参考依据。方法回顾性分析2022年4月至2023年4月于呼和浩特市第一医院门诊及住院治疗的老年高血压合并颈动脉粥样硬化患者的临床资料,将其作为观察组,另收集同期门诊及住院高血压患者的资料作为对照组。所有研究对象均进行血清载脂蛋白A-Ⅰ及颈血管彩超的检测。比较上述指标的变化情况,并分析老年高血压患者载脂蛋白A-Ⅰ与颈动脉粥样硬化的相关性。结果观察组研究对象载脂蛋白A-Ⅰ水平低于对照组,颈动脉血管彩超检查,观察颈内动脉、颈外动脉、颈总动脉的最大流速(V max)、最小流速(V min)、阻力指数RI、管径、内中膜厚度、斑块的大小、颈动脉狭窄差异均有统计学意义(P<0.05)。结论老年高血压患者载脂蛋白A-Ⅰ水平越低,颈动脉粥样硬化程度水平越高,且载脂蛋白A-Ⅰ与颈血管血流、颈动脉狭窄水平呈显著正相关。临床可应用载脂蛋白A-Ⅰ水平控制作为老年高血压合并颈动脉粥样硬化患者的早期干预指标,有助于延缓老年高血压患者颈动脉粥样硬化的发生,从而降低心脑血管病的发生率、致残率。Objective To investigate the correlation between apolipoprotein A-Ⅰand carotid atherosclerosis in elderly hypertensive patients,and to provide reference for early intervention of risk factors in elderly hypertensive patients.Methods Clinical data of elderly patients with hypertension combined with carotid atherosclerosis in outpatient and inpatient departments of Hohhot First Hospital from April 2022 to April 2023 were retrospectively analyzed,and they were selected as the observation group,and the data of outpatient and inpatient hypertension patients during the same period were selected as the control group.All subjects underwent serum apolipoprotein A-Ⅰand carotid blood vessel color ultrasonography.The changes of the above indexes were compared,and the correlation between apolipoprotein A-Ⅰand carotid atherosclerosis in elderly patients with hypertension was analyzed.Results The apolipoprotein A-Ⅰlevel in the observation group was lower than that in the control group.The maximum flow velocity(V max)and minimum flow velocity(V min)of internal carotid artery,external carotid artery and common carotid artery were observed by color Doppler ultrasound.There were significant differences in V max,V min,resistance index RI,tube diameter,intismal thickness,plaque size and carotid artery stenosis(all P<0.05).Conclusion The lower the level of apolipoprotein A-Ⅰwas,the higher the degree of carotid atherosclerosis was,and there was a significant positive correlation between apolipoprotein A-Ⅰand carotid blood flow and carotid artery stenosis.Apolipoprotein A-Ⅰlevel control can be used as an early intervention indicator for elderly patients with hypertension combined with carotid atherosclerosis,which helps to delay the occurrence of carotid atherosclerosis in elderly patients with hypertension,thus reducing the incidence of cardiovascular and cerebrovascular diseases and the rate of disability.

关 键 词：高血压 老年高血压 载脂蛋白A-Ⅰ 低密度脂蛋白胆固醇 颈动脉粥样硬化 

分 类 号：R544.1[医药卫生—心血管疾病] R543.4[医药卫生—内科学]