生殖道HPV感染孕妇血清孕酮雌二醇表达水平及其对妊娠结局的影响  

Expression levels of serum progesterone and estradiol in pregnant women infected with genital HPV and their influences on pregnancy outcomes

作　　者：杨创杰 彭皎 Yang Chuangjie;Peng Jiao(Sanmenxia Hospital of Traditional Chinese Medicine,Sanmenxia 472000,Henan,China)

机构地区：[1]三门峡市中医院,河南三门峡472000

出　　处：《临床心身疾病杂志》2024年第2期46-50,共5页Journal of Clinical Psychosomatic Diseases

基　　金：河南省医学科技攻关计划联合共建项目(编号LHGJ20210450)。

摘　　要：目的 探讨生殖道人乳头瘤病毒(HPV)感染孕妇血清孕酮、雌二醇表达水平及妊娠结局的影响因素。方法 选取101例生殖道HPV感染孕妇设为观察组,另选取50例无HPV感染的健康孕妇设为对照组。检测HPV感染分型,记录新生儿HPV阳性检出率;对比两组孕妇血清孕酮、雌二醇水平;记录不良妊娠结局,Logistic回归分析影响妊娠结局的因素。制作受试者工作特征(ROC)曲线,以曲线下面积(AUC)评估血清孕酮、雌二醇及两者联合对生殖道HPV感染孕妇妊娠结局的预测效能。结果 生殖道HPV感染孕妇低危型48例,高危型53例,新生儿HPV阳性检出率为40.59%。观察组孕妇血清孕酮、雌二醇水平均低于对照组,不良妊娠结局总发生率高于对照组(P<0.01)。有不良妊娠结局组孕妇的血清孕酮、雌二醇水平均低于无不良妊娠结局组(P<0.01)。多因素分析结果显示,血清孕酮、雌二醇是影响生殖道HPV感染孕妇妊娠结局的危险因素(OR=1.578、1.839,P<0.01)。ROC曲线分析结果显示,血清孕酮、雌二醇及两者联合对生殖道HPV感染孕妇妊娠结局预测的AUC为0.813、0.809、0.902。结论 临床上可通过检测生殖道HPV感染孕妇血清孕酮、雌二醇水平对不良妊娠结局进行评估。Objective To explore serum progesterone and estradiol expression level and factors influencing pregnancy outcomes in pregnant women infected with genital tract human papillomavirus(HPV).Methods A total of 101 pregnant women with genital HPV infection were selected as observation group and 50 healthy pregnant women as control group.The types of HPV infection were detected and positive detection rate of neonatal HPV recorded;serum progesterone and estradiol levels were compared between two groups;adverse pregnancy outcomes were recorded and influencing factors of pregnancy outcome analyzed using Logistic regression.Receiver operating characteristic(ROC) curve was made,the area under the curve(AUC) used to evaluate the separate progesterone,estradiol and their combination prediction efficacy in pregnant women with genital HPV infection.Results Pregnant women with low-risk HPV infection were 48,high-risk ones 53,and the positive detection rate of neonatal HPV was 40.59%.Serum progesterone and estradiol level were lower and total incidence of adverse pregnancy outcome was higher in observation than control group(P<0.01).Serum progesterone and estradiol level were lower in pregnant women with adverse pregnancy outcome than ones without(P<0.01).Multivariate analysis showed that serum progesterone and estradiol were the risk factors influencing the pregnancy outcome of pregnant women with genital HPV infection(OR=1.578,1.839;P<0.01).ROC analysis showed that the AUC of separate progesterone,estradiol and their combination in predicting the pregnancy outcome of pregnant women with genital HPV infection were 0.813,0.809 and 0.902.Conclusion The adverse pregnancy outcome can be evaluated via detecting the serum progesterone and estradiol levels of pregnant women with genital HPV infection clinically.

关 键 词：孕妇 人乳头瘤病毒 孕酮 雌二醇 妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学]