A型肉毒毒素联合注射改善面颈部老化的效果及安全性  

Efficacy and safety of botulinum toxin type A in improving face and neck aging

作　　者：魏妍 余怡恒 鲁亚青 杨莉 李雪莉[1,2,3] Wei Yan;Yu Yiheng;Lu Yaqing;Yang Li;Li Xueli(Xinxiang Medical College,Xinxiang 453000,China;Department of Dermatology,Henan Provincial People′s Hospital,Zhengzhou 450003,China;Department of Dermatology,People′s Hospital of Zhengzhou University,Zhengzhou 450003,China)

机构地区：[1]新乡医学院,新乡453000 [2]河南省人民医院皮肤科,郑州450003 [3]郑州大学人民医院皮肤科,郑州450003

出　　处：《中华医学美学美容杂志》2024年第1期13-18,共6页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：河南省医学科技攻关计划(LHGJ20220015)。

摘　　要：目的:评估A型肉毒毒素联合注射改善面颈部老化的临床效果及安全性。方法:2020年1月至2023年1月,在河南省人民医院皮肤科进行面颈部联合注射A型肉毒毒素女性患者30例,年龄29~66(42.2±8.8)岁。注射部位包括额部、眉间、眼周、鼻背、下颌缘等,注射后4、24周通过皱纹严重程度量表(facial wrinkle scale,FWS)、半颜面中线上下颌缘最低点到内眦水平线距离AB值评估疗效,同时通过面部整体美学改善量表(global aesthetic improvement scale,GAIS)及自我年龄感知(self-perception of age,SPA)评估患者的主观改善度,并评估患者满意度及注射后不良反应。结果:注射后4周时,上面部各部位皱纹改善总有效30例(100%),AB值改善差异有统计学意义(t=28.35,P<0.05)。注射后24周时,上面部各部位皱纹改善总有效率为16.7%(5/30)~36.7%(11/30),AB值改善差异有统计学意义(t=3.98,P<0.05)。注射后4周和24周时分别有100%(30/30)和66.7%(20/30)患者经GAIS评估面部状态得到了改善,100%(30/30)和63.3%(19/30)患者认为自己变年轻。患者满意度100%(30/30)。注射后有注射部位轻微瘀斑5例、眉毛上抬无力1例,均在1~2周内自行消失。结论:A型肉毒毒素面颈部联合注射在面部年轻化的治疗效果明显,患者满意度较高,且无严重不良反应。Objective To evaluate the clinical effectiveness and safety of combined face and neck injections of botulinum toxin type A to improve face and neck aging.Methods From January 2020 to January 2023,30 female patients with age of 29-66 years,average(42.2±8.8)years,underwent face and neck combined injection of A-type botulinum toxin in the Department of Dermatology,Henan Provincial People′s Hospital.The injection sites included the forehead,between the eyebrows,around the eyes,the dorsum of the nose,and the mandibular margin,etc.The efficacy was assessed by the wrinkle severity scale(FWS)and the AB value of the distance from the lowest point of the mandibular margin on the midline of the hemiface to the level of the medial canthus at 4 and 24 weeks after the injection,as well as the subjective degree of improvement by the Global Aesthetic Improvement of the Face Scale(GAIS)and the Self-perception of Age(SPA),and the satisfaction of the patients and post-injection adverse reactions.Results At 4 weeks after the injection,the total effective rate of improvement of wrinkles in all parts of the upper face was 100%(30/30),and there was a statistically significant difference in the improvement of AB(t=28.35,P<0.05).At 24 weeks after the injection,the total effective rate of improvement of wrinkles in all parts of the upper face ranged from 16.7%(5/30)to 36.7%(11/30),and the improvement of AB still showed a statistically significant difference(t=3.98,P<0.05).100%(30/30)and 66.7%(20/30)of patients assessed their facial status as improved on GAIS at 4 and 24 weeks after the injection,respectively,and 100%(30/30)and 63.3%(19/30)of patients perceived themselves as younger.Patient satisfaction was 100%(30/30).After injection,there were 5 cases of slight ecchymosis at the injection site and 1 case of weakness in eyebrow elevation in the 30 patients,which disappeared on their own within 1 to 2 weeks.Conclusions The therapeutic effect of face and neck combined injection of botulinum toxin type A on facial rejuvenation is obvious,

关 键 词：肉毒毒素类 面颈部 除皱 下面部提升 满意度 

分 类 号：R62[医药卫生—整形外科]