NLRP6在抗细菌感染免疫中的作用研究进展  

Advances in studies on the role of NLRP6 in host immunity against bacterial infection

作　　者：曹宇[1,2] 龚亚婷 吴淑燕 黄瑞[1] CAO Yu;GONG Yating;WU Shuyan;HUANG Rui(School of Biology&Basic Medical Science,Suzhou Medical College of Soochow University,Suzhou 215123,Jiangsu Province,China;Laboratory Department,Children’s Hospital of Soochow University,Suzhou 215025,Jiangsu Province,China)

机构地区：[1]苏州大学苏州医学院基础医学与生物科学学院,江苏苏州215123 [2]苏州大学附属儿童医院检验科,江苏苏州215025

出　　处：《微生物与感染》2023年第6期358-363,共6页Journal of Microbes and Infections

基　　金：国家自然科学基金面上项目(81971899,31670140)。

摘　　要：含热蛋白结构域的核苷酸结合寡聚化结构域样受体蛋白6(nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6,NLRP6)是宿主固有免疫重要的胞内模式识别受体之一,参与机体感染、炎症、肿瘤和代谢性疾病的调节。它可通过感知细菌、病毒、真菌和寄生虫等病原生物及其产物,如革兰氏阳性菌脂磷壁酸(lipoteichoic acid,LTA)和病毒双链RNA,调节机体抗感染免疫效应,减弱或增强宿主的抵抗力,从而影响感染的转归。本文就NLRP6的结构与功能及其在抗细菌感染免疫中的作用研究作综述。Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6(NLRP6)is one of the important intracellular pattern recognition receptors of host innate immunity and is involved in the regulation of infection,inflammation,tumor and metabolic diseases.By sensing pathogenic organisms such as bacteria,viruses,fungi,parasites and their products,such as lipoteichoic acid(LTA)of Gram-positive bacterium and viral double-stranded RNA,it can regulate the anti-infection immune effect of the body,weaken or enhance the host resistance and affect the outcome of infection.This article reviews the structure and function of NLRP6 and its role in host immunity against bacterial infection.

关 键 词：含热蛋白结构域的核苷酸结合寡聚化结构域样受体蛋白6 细菌 抗感染免疫 

分 类 号：R378[医药卫生—病原生物学]