双耳分听模式下汉语语言信号和韵律信号的处理:一项fMRI研究  

Processing of Chinese linguistic and prosodic signals in dichotic listening conditions:A fMRI study

作　　者：徐紫薇 莫茵[1] 史尧平 蔡希睿 XU Ziwei;MO Yin;SHI Yaoping;CAI Xirui(Department of Medical Imaging,the First Affiliated Hospital of Kunming Medical University,Kunming 650000,China;Department of Medical Imaging,First People's Hospital of Changde,Changde 415000,China;Department of Foreign Languages,Kunming Medical University,Kunming 650500,China)

机构地区：[1]昆明医科大学第一附属医院医学影像科,昆明650000 [2]常德市第一人民医院医学影像科,常德415000 [3]昆明医科大学外语部,昆明650500

出　　处：《磁共振成像》2024年第2期115-121,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:82160275);云南省教育厅科学研究基金项目(编号:2023J0340)。

摘　　要：目的为了探讨汉语为母语者在处理双耳分听模式下汉语听觉信号的脑区分布特征及偏侧化特点,本研究利用低通过滤的方法获取韵律信号,结合双耳分听技术,通过脑功能磁共振成像得到汉语语言和韵律双耳分听信号的神经处理模型。材料与方法从2022年1月至5月在昆明医科大学第一附属医院共招募30位志愿者,年龄(25.36±0.88)岁,汉语为母语,强右利手者。汉语短句音频信号通过低通滤波器,只保留低频率语言韵律信号(<320 Hz),并得到两组双耳分听语音信号:左耳低通过滤右耳不过滤组(filtered in the left ear and unfiltered in the right ear,FL);右耳低通过滤左耳不过滤组(filtered in the right ear and unfiltered in the left ear,FR)。受试者依次聆听两组语音信号,同时进行两组组块设计的脑功能磁共振成像。使用SPM 12软件对得到的影像数据进行预处理后,进行组内单样本t检验、组间双样本t检验,以此观察两组语音信号激活脑区的分布和强度的共性、差异性。根据单样本t检验的统计结果,确定感兴趣区域,计算相应脑区的偏侧化指数,以获得大脑在处理双耳分听模式下的汉语语言和韵律信号时的脑区偏侧化特点。结果两组信号都激活了双侧颞中回、颞上回、额下回,左侧中央前回和右侧额中回(P<0.05,FDR校正);FL信号诱导左侧额中回血氧水平增高(P<0.05,FDR校正);FR信号还激活了双侧顶下小叶(P<0.05,FDR校正)。对两组语音信号进行双样本t检验后,发现FR与FL相比,右侧颞中回、颞上回具有明显差异(P<0.05,FDR校正);FL与FR相比无明显差异性脑区。对两组语音信号进行偏侧化指数计算后发现,在大脑半球水平上两组语音信号无明显的偏侧化表现。两组信号的额中回具有右侧优势,中央前回都表现出左侧化趋势;顶下小叶在FR刺激下呈现左侧化趋势。结论大脑处理两种语音信号时具有一个由双侧颞中回、�Objective:This study aims to investigate the brain activation areas and lateralization patterns of native Chinese speakers processing auditory language signals in dichotic listening conditions.It utilizes the low-pass filtering method and dichotic listening technique to derive neural processing models through functional magnetic resonance imaging(fMRI).Materials and Methods:Thirty participants(age 25.36±0.88 years,native Chinese speakers,and strongly right-handed)participated in the study from January to May 2022 in the First Affiliated Hospital of Kunming Medical University.Chinese short sentences were low-pass filtered(<320 Hz),retaining only low-frequency prosodic information.Auditory signals were presented in two dichotic listening conditions:filtered in the left ear and unfiltered in the right ear(FL),and filtered in the right ear and unfiltered in the left ear(FR).Participants alternately listened to two groups of signals,while two sessions of block-design fMRI scanning were conducted.After preprocessing the image data using SPM 12 software,one-sample t-tests within the group and two-sample t-tests between the groups were performed to identify similarities and differences in the distribution and intensity of brain activation areas during signal processing.Regions of interest(ROIs)were identified based on the one-sample t-tests,and the lateralization indices of the ROIs were then calculated to determine lateralization patterns.Results:Both signal groups activated the bilateral middle temporal,superior temporal,inferior frontal,the left precentral,and the right middle frontal gyri(P<0.05,FDR-corrected).Additionally,FL signals led to increased blood oxygen levels in the left frontal gyrus(P<0.05,FDR-corrected),and FR signals activated the bilateral inferior parietal lobule(P<0.05,FDR-corrected).Two-sample t-tests revealed significant differences in the right middle temporal gyrus and superior temporal gyrus in the contrast of FR vs.FL(P<0.05,FDR-corrected).No significant difference was observed in the contras

关 键 词：听觉语言信号 低通过滤 韵律 双耳分听 脑功能磁共振成像 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.81[医药卫生—诊断学]