磁共振脂肪定量技术在肝脏肿瘤中的应用  

Application of magnetic resonance fat quantification technique in liver tumors

作　　者：夏娟 李梁[1] 余成新[1] 潘君龙[1] 胡军[1] XIA Juan;LI Liang;YU Chengxin;PAN Junlong;HU Jun(Department of Radiology,the First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China)

机构地区：[1]三峡大学第一临床医学院放射科,宜昌443003

出　　处：《磁共振成像》2024年第2期224-228,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：湖北省卫生厅科研项目(编号:WJ2021M065)。

摘　　要：体内器官的脂肪堆积会增加包括肝良性病变在内的多种疾病癌变的风险。近年来,脂肪性肝病越来越被认为是肝细胞癌的危险因素,与代谢相关脂肪性肝病相关的肝细胞癌已是全球日益增加的医疗负担。肝肿瘤瘤内及瘤周脂肪含量在肿瘤的诊断、鉴别、分级及预后等方面有一定价值。肝移植作为肝肿瘤治疗手段之一越来越受到重视,肝脏脂肪变性与肝移植术前评估及术后监测密切相关。除此之外,肿瘤治疗过程中所致肝损伤也与肝脏脂肪含量直接相关。因此,肝脏脂肪定量在肝脏肿瘤的发生发展、诊断治疗及预后评估中具有重要意义。本文综述了磁共振波谱成像(magnetic resonance spectroscopy,MRS)、化学位移成像(chemical shift imaging,CSI)以及多回波Dixon(包括IDEAL-IQ和mDixon-Quant)等MRI脂肪定量技术在肝脏肿瘤中的应用,旨在提供更精准定量肝脏脂肪的影像标志物,为肿瘤治疗方式的选择和疗效评估提供客观和科学的依据,用以帮助临床对肝脏肿瘤进行无创诊断及治疗评估。Accumulation of fat in body organs increases the risk of cancer in various diseases,including benign liver lesions.In recent years,fatty liver disease has been increasingly recognized as a risk factor for hepatocellular carcinoma,and hepatocellular carcinoma associated with metabolism-associated fatty liver disease has been a growing healthcare burden worldwide.The intratumoral and peritumoral fat content of liver tumors is valuable in the diagnosis,differentiation,grading,and prognosis of liver tumors.Liver transplantation has received increasing attention as one of the therapeutic means for liver tumors,and hepatic steatosis is closely related to preoperative evaluation and postoperative monitoring of liver transplantation.In addition,liver injury caused during tumor treatment is also directly related to liver fat content.Therefore,liver fat quantification is of great significance in developing liver tumors,diagnosis and treatment,and prognosis assessment.In this paper,we review the application of MRI fat quantification techniques,including magnetic resonance spectroscopy(MRS),chemical shift imaging(CSI),and multi-echo Dixon techniques(including IDEAL-IQ and mDixon-Quant)in liver tumors aim to provide more accurate quantitative liver fat imaging marker,to provide an objective and scientific basis for the selection of tumor treatment modalities and the assessment of efficacy,which can be used to help the clinical non-invasive diagnosis and therapeutic evaluation of liver tumors.

关 键 词：肝脏肿瘤 脂肪定量 磁共振成像 多回波Dixon技术 

分 类 号：R445.2[医药卫生—影像医学与核医学] R735.7[医药卫生—诊断学]