载木犀草素纳米纤维膜的制备与性能  

Preparation and Properties of Nanofiber MembranesLoaded with Luteolin

作　　者：刘明迪 邹梦君 周菊英 许海棠 赵彦芝 Liu Mingdi;Zou Mengjun;Zhou Juying;Xu Haitang;Zhao Yanzhi(School of Chemistry and Chemical Engineering,Guangxi Minzu University,Nanning,Guangxi,530006;Key Laboratory of Chemistry and Engineering of Forest Products,State Ethnic Affairs Commission,Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products,Nanning,Guangxi,530006)

机构地区：[1]广西民族大学化学化工学院,广西南宁530006 [2]林产化学与工程国家民委重点实验室,广西林产化学与工程重点实验室,广西林产化学与工程协同创新中心,广西南宁530006

出　　处：《现代塑料加工应用》2024年第1期1-4,共4页Modern Plastics Processing and Applications

基　　金：国家自然科学基金项目(52063004)。

摘　　要：采用2种pH敏感材料(Eudragit S100和Eudragit RS100),通过同轴静电纺丝技术制备了壳/核结构载木犀草素纳米纤维膜,通过扫描电子显微镜(SEM)、透射电子显微镜(TEM)、傅里叶变换红外光谱仪(FTIR)、X射线衍射仪(XRD)等研究了壳/核结构载木犀草素纳米纤维膜的表面形貌、化学结构和药物释放性能。结果表明:壳/核结构载木犀草素纳米纤维膜表面整体较光滑,纳米纤维平均直径随木犀草素含量增加而增大。该纳米纤维膜具有良好的结肠靶向性和生物相容性。Two pH sensitive materials(Eudragit S100 and Eudragit RS100)were used to prepare shell/core structure nanofiber membranes loaded with luteolin by coaxial electrospinning technology.The surface morphology,chemical structure and drug release performance of shell/core structure nanofiber membranes loaded with luteolin were studied by scanning electron microscopy(SEM),transmission electron microscopy(TEM),Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD)and so on.The results show that the surface of shell/core structure nanofiber membranes loaded with luteolin is generally smooth.The average diameter of the nanofibers increases with the increase of luteolin content.The nanofiber membrane has good colon targeting and biocompatibility.

关 键 词：同轴静电纺丝技术 壳/核结构 木犀草素 结肠靶向 缓释控释 

分 类 号：TB383.2[一般工业技术—材料科学与工程] TQ340.64[化学工程—化纤工业]