慢性咳嗽与中枢神经因子调节剂的利用  

Use of central neuromodulators in chronic cough

作　　者：沙炳先 白昊东 李婉珍 余莉[1] 徐镶怀[1] SHA Bingxian;BAI Haodong;LI Wanzhen;YU Li;XU Xianghuai(Department of Pulmonary and Critical Care Medicine,Tongji Hospital,School of Medicine,Tongji University,Shanghai 200065,China)

机构地区：[1]同济大学附属同济医院呼吸与危重症医学科,上海200065

出　　处：《中国临床药理学与治疗学》2024年第4期432-439,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金面上项目(82270114,82070102);上海市科委医学创新研究专项项目(22Y11901300,21Y11901400);上海市科委自然科学基金面上项目(20ZR1451500);上海市优秀学术带头人项目(22XD1422700)。

摘　　要：慢性咳嗽是一种常见的疾病,但会给患者带来巨大的身体、精神和社会负担。虽然慢性咳嗽通常与基础疾病,如哮喘、胃食管反流病、嗜酸性粒细胞性支气管炎等相关,但是部分患者咳嗽极难控制,并且难以明确咳嗽病因,其中许多患者表现出咳嗽高敏感性的临床特征,这为慢性咳嗽的治疗研究提供了新的方向。随着对慢性咳嗽病理生理学机制的深入研究,慢性咳嗽的治疗方法发展到新阶段。本文总结并讨论了中枢神经因子调节剂用于治疗慢性咳嗽的机制以及临床证据,这些药物可能在未来有较好的临床应用前景。Chronic cough is a common condition that imposes significant physical,psychological,and social burdens on patients.Although chronic cough is often associated with underlying conditions such as asthma,gastroesophageal reflux disease,and eosinophilic bronchitis,some patients experience uncontrollable coughing that is difficult to attribute to a specific cause.Many of these patients exhibit clinical features of cough hypersensitivity syndrome,providing new directions for research into the treatment of chronic cough.As the pathophysiological mechanisms of chronic cough are further elucidated,treatment approaches for chronic cough are entering a new stage of development.This article summarizes and discusses the mechanisms and clinical evidence of central neuromodulators used in the treatment of chronic cough,suggesting promising clinical applications for these drugs in the future.

关 键 词：慢性咳嗽 神经调节剂 咳嗽高敏综合征 

分 类 号：R562[医药卫生—呼吸系统]