复合纳米载体在微波可控释药方面的研究进展  

Research Progress of Composite Nanocarriers for Microwave-Controlled Drug Release

作　　者：刘雪茹 刘叶 刘超[4] 惠壮 崔斌 LIU Xueru;LIU Ye;LIU Chao;HUI Zhuang;CUI Bin(School of Chemistry and Materials Sci.,Northwest Univ.,Xi’an 710127,China;National Chemical Experimental Teaching Demonstration Center(Northwest Univ.),Xi’an 710127,China;School of Freshmen,Xi’an Technol.Univ.,Xi’an 710021,China;School of Chemistry and Chemistry Eng.,Central South Univ.,Changsha 410083,China)

机构地区：[1]西北大学化学与材料科学学院,陕西西安710127 [2]西北大学化学国家级实验教学示范中心(西北大学),陕西西安710127 [3]西安工业大学新生院,陕西西安710021 [4]中南大学化学与化工学院,湖南长沙410083

出　　处：《工程科学与技术》2024年第2期139-150,共12页Advanced Engineering Sciences

基　　金：陕西省教育厅一般专项项目(21JK0938)。

摘　　要：在现代癌症治疗中,传统化疗药物缺乏靶向性,常伴随严重的毒副作用,限制了化学疗法的临床应用。近年来,随着纳米技术的发展,基于纳米材料的靶向化疗成为一种新的治疗策略,特别是复合纳米材料在微波刺激下的药物释放性能,展现出了优异的应用前景。本文综述了这一领域的最新进展,重点分析了复合纳米材料如何在微波刺激下实现精准的药物释放,以及这种方法在癌症治疗中的潜力。复合纳米材料因其独特的物理化学性质,如高稳定性和良好的生物相容性,被广泛应用于癌症治疗中。在微波刺激下,这些材料能够实现药物的精准控制释放,从而提高治疗效果并减少对健康组织的损害。然而,复合纳米载体在生物体内的分布、靶向性和生物安全性等方面仍面临一定的挑战。例如,纳米粒子的体内稳定性和靶向能力需要进一步优化,以提高其治疗效果和减少副作用。在微波刺激诱导的药物控制释放方面,虽然已取得了一定的成果,但精确控制微波能量的传递和局部组织的加热效果仍是主要挑战之一。此外,如何确保微波能量集中于肿瘤组织而不损害周围健康组织,也是当前研究需要解决的问题。未来,随着纳米技术的不断进步和微波控制技术的改进,预计将开发出更为高效和安全的复合纳米载体,不仅能够提高药物的靶向性和治疗效果,还能在微波刺激下实现更为精准的药物释放控制。综上所述,复合纳米材料在微波刺激下的药物释放性能将是癌症治疗领域的一个重要研究方向,有望为癌症患者带来更有效的治疗选择。In contemporary cancer therapy,traditional chemotherapy drugs often lack specificity and are frequently accompanied by severe side effects,restricting their clinical utility.In recent years,advancements in nanotechnology have yielded targeted chemotherapy using nanomaterials as a promising,new treatment strategy.Specifically,the drug release capabilities of composite nanomaterials under microwave stimulation have shown remarkable potential.This paper provides an overview of the latest developments in this field,focusing on how composite nanomaterials can achieve precise drug release under microwave stimulation and their potential impact on cancer treatment.Composite nanomaterials find wide-spread application in cancer treatment due to their unique physicochemical properties,such as high stability and excellent biocompatibility.When exposed to microwave stimulation,these materials can precisely control drug release,enhancing therapeutic efficacy while minimizing harm to healthy tissues.Nevertheless,composite nanocarriers face certain challenges,including issues related to their distribution within the body,target-ing precision,and overall biocompatibility.For instance,further optimization is necessary to improve in vivo stability and targeting capabilities of nanoparticles to maximize treatment effectiveness while minimizing side effects.Regarding microwave-induced controlled drug release,despite considerable progress,achieving precise control over microwave energy delivery and local tissue heating continues to pose a major challenge.Ad-ditionally,ensuring that microwave energy is concentrated on tumor tissues without adversely affecting surrounding healthy tissues is an ongoing research concern.In the future,as nanotechnology continues to advance and microwave control techniques improve,it is anticipated that more ef-ficient and safer composite nanocarriers will be developed.These advanced carriers have the potential not only to enhance drug targeting and treatment effectiveness but also to achieve even more prec

关 键 词：复合纳米材料 纳米载体 靶向给药 微波可控释药 

分 类 号：TB34[一般工业技术—材料科学与工程]