补肾养肝方配合西药治疗围绝经期综合征的疗效及对性激素、生活质量的影响  

Curative Effect of Bushen Yanggan Prescription Combined with Western Medicine for Perimenopausal Syndrome and Its Effect on Sex Hormones and Quality of Life

作　　者：余颖华 刘继峰 叶锦霞 王宏丽 陈金芳 YU Yinghua;LIU Jifeng;YE Jinxia;WANG Hongli;CHEN Jinfang(Department of Gynecology,Hangzhou Gongshu District Shiqiao Street Community Health Service Center,Hangzhou Zhejiang 310000,China)

机构地区：[1]杭州市拱墅区石桥街道社区卫生服务中心妇科,浙江杭州310000

出　　处：《新中医》2024年第3期73-77,共5页New Chinese Medicine

摘　　要：目的:观察补肾养肝方配合西药治疗围绝经期综合征(PMS)的疗效及对患者性激素、生活质量的影响。方法:选取98例PMS患者为研究对象,按随机数字表法分为观察组与对照组各49例。对照组口服戊酸雌二醇、黄体酮胶囊,观察组在此基础上加服补肾养肝方。比较2组临床疗效及不良反应发生率,比较2组治疗前后中医证候积分、性激素水平及生活质量。结果:治疗后,2组烘热出汗、易怒急躁、情绪变化、头晕耳鸣、腰酸背痛、心悸胸闷、失眠多梦等中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05)。观察组总有效率91.84%,高于对照组75.51%(P<0.05)。治疗后,2组雌二醇(E2)水平升高(P<0.05),且观察组高于对照组(P<0.05);2组卵泡刺激素(FSH)、促黄体生成激素(LH)水平均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组心理领域、生理领域、环境领域、社会关系领域世界卫生组织生活简易量表(WHOQOL-BREF)评分均升高(P<0.05),且观察组高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:补肾养肝方配合西药治疗PMS,可有效提高临床疗效,对改善患者性激素水平及生活质量具有积极作用,效果安全可靠。Objective:To observe the curative effect of Bushen Yanggan Prescription combined with western medicine for perimenopausal syndrome(PMS) and its effect on sex hormones and quality of life.Methods:A total of 98 cases of PMS patients were selected as the study objects and were divided into the observation group and the control group according to the random number table method,with 49 cases in each group.The control group was given the oral administration of Estradiol Valerate and Progesterone Capsules,and the observation group was additionally treated with Bushen Yanggan Prescription.The clinical effects and the incidence of adverse reactions were compared between the two groups;traditional Chinese medicine(TCM) syndrome scores,sex hormone levels and quality of life were compared before and after treatment between the two groups.Results:After treatment,the scores of TCM syndromes such as hot flashes and sweating,irascibility and irritability,mood changes,dizziness and tinnitus,low back pain,palpitation and chest oppression,insomnia and profuse dreaming in the two groups were decreased(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).The total effective rate was 91.84% in the observation group,higher than that of 75.51%in the control group(P<0.05).After treatment,the levels of estradiol(E2) in the two groups were increased(P<0.05),and the level in the observation group was higher than that in the control group(P<0.05).The levels of follicle-stimulating hormone(FSH) and luteinizing hormone(LH) in the two groups were decreased(P<0.05),and the levels in the observation group were lower than those in the control group(P<0.05).After treatment,the scores of WHO Quality of Life Brief Scale(WHOQOL-BREF) in psychological,physiological,environmental and social relations fields in the two groups were increased(P<0.05),and the scores in the observation group were higher than those in the control group(P<0.05).There was no significant difference being found in the comparison

关 键 词：围绝经期综合征 补肾养肝方 性激素 生活质量 中医证候积分 

分 类 号：R711.75[医药卫生—妇产科学]