含苯并噻唑环水杨醛Schiff碱化合物的合成及其抑菌实验  

Synthesis and Antibacterial Activity of Salicylaldehyde Schiff Base Containing Benzothiazole Ring

作　　者：叶红德 董选文 肖琼 徐贵人 黄艳 张小兰 彭化南 张洲 YE Hongde;DONG Xuanwen;XIAO Qiong;XU Guiren;HUANG Yan;ZANGH Xiaolan;PENG Huanan;ZHANG Zhou(School of Chemistry and Environmental Science,Jiangxi Provincial Research of Targeting Pharmaceutical Engineering Technology,Shangrao Normal University,Shangrao Jiangxi 334001,China;School of Chemistry and Environmental Science,Shangrao Key Laboratory of Ecotoxicology,Shangrao Normal University,Shangrao Jiangxi 334001,China;Qingyun Middle School of Wannian County of Jiangxi Province,Shangrao Jiangxi 335511,China)

机构地区：[1]上饶师范学院化学与环境科学学院江西省靶向药物工程技术研究中心,江西上饶334001 [2]上饶师范学院化学与环境科学学院上饶市生态毒理学重点实验室,江西上饶334001 [3]江西万年县青云中学,江西上饶335511

出　　处：《上饶师范学院学报》2023年第6期37-42,共6页Journal of Shangrao Normal University

基　　金：国家自然科学基金(62065016,21361022);江西省自然科学基金(20202BABL202023);江西省教育厅科技计划项目(GJJ190883,GJJ211707);上饶市科技局计划项目(SKB2021005,20201002);上饶师范学院大学生创新训练项目(202310416002)。

摘　　要：对硝基苯甲醛和2-甲基苯并噻唑反应生成化合物(E)-2-(4-硝基苯乙烯基)苯并噻唑(1)。化合物1用铁粉和氯化铵还原得到化合物(E)-2-(4-氨基苯乙烯基)苯并噻唑(2)。化合物2和水杨醛反应得到含苯并噻唑环水杨醛Schiff碱化合物3。对化合物1、2、3分别用熔点、红外和核磁等表征方法进行结构表征。初步抗菌实验结果显示:化合物3对大肠杆菌、金色葡萄球菌和黑曲霉菌均具有很好的抑菌效果。P-nitrobenzaldehyde was treated with 2-methylbenzothiazole to obtain the compound trans-2-[4-nitrostyryl]benzothiazole(1).The compound 1 was reduced by iron powder&ammonium chloride to form the compound trans-2-[4-aminostyryl]benzothiazole(2).The reaction of the compound 2 with salicylaldehyde afforded Schiff base produced compound 3 containing benzothiazole ring.The compounds 1,2 and 3 have been characterized by melting point,IR and~(1)H NMR.Preliminary antibacterial experiment results showed that the compound 3 exhibited certain antibacterial activities against Escherichia coli,Staphylococcus aureus and Aspergillus niger.

关 键 词：2-甲基苯并噻唑 水杨醛 SCHIFF碱 抑菌作用 

分 类 号：O626.25[理学—有机化学]