血清25羟基维生素D_(3)水平与供精人工授精妊娠相关结局的关系  

Association of the Serum 25-Hydroxy Vitamin D_(3)Level with the Pregnancy Outcomes of Artificial Insemination by Donor

作　　者：宋瑞芳 吴成平 邢冠琳 杨晓亮 王芳 SONG Ruifang;WU Chengping;XING Guanlin;YANG Xiaoliang;WANG Fang(Department of Reproductive Medicine,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000,China)

机构地区：[1]郑州大学附属洛阳中心医院生殖医学科,河南洛阳471000

出　　处：《河南医学研究》2024年第4期625-628,共4页Henan Medical Research

基　　金：河南省科技攻关项目(212102310463)。

摘　　要：目的探讨血清25羟基维生素D_(3)[25(OH)D_(3)]水平与供精人工授精(AID)妊娠相关结局的关系。方法选取2020年1月至2022年6月于郑州大学附属洛阳中心医院生殖医学科行AID治疗并测定血清25(OH)D_(3)水平的患者共279例。根据血清25(OH)D_(3)水平将患者分为维生素D缺乏组[25(OH)D_(3)<30μg·L^(-1),199例]和正常组[25(OH)D_(3)≥30μg·L^(-1),80例]。比较两组患者一般资料、临床妊娠率、流产率、活产分娩率,再进行二元logistic回归分析探索影响妊娠结局的相关因素。结果两组间自然周期占比、2次手术占比、术日≥18 mm平均卵泡数、年龄、体重指数、手术日内膜厚度、不孕年限以及注入宫腔内精子数、Gn用量、临床妊娠率、流产率、活产分娩率等差异无统计学意义(P>0.05),两组间抗苗勒管激素水平差异有统计学意义(P<0.05)。运用多因素二元logistic回归模型分析显示,血清25(OH)D_(3)水平并不是影响临床妊娠的独立因素(P>0.05)。结论血清25(OH)D_(3)与AID临床妊娠结局无相关性;年龄是临床妊娠结局的危险因素。Objective To explore the association of the 25-hydroxy vitamin D_(3)[25(OH)D_(3))]level in the serum with the pregnancy outcome of artificial insemination by donor(AID).Methods A total of 279 infertile women that under AID and detection of serum 25(OH)D_(3)in the Department of Reproductive Medicine of Luoyang Central Hospital Affiliated to Zhengzhou University from January 2020 to June 2022 were selected.According the level of serum 25(OH)D_(3),the patients were divided into vitamin D deficiency groups[25(OH)D_(3)<30μg·L^(-1),199 cases]and normal group[25(OH)D_(3)≥30μg·L^(-1),88 cases].The basic information and the rates of clinical pregnancy,rates of abortion and rate of live birth were compared between the two groups,and the factors affecting the early pregnancy outcome were investigated using binary logistic regression analysis.Results There were no statistically significant differences in natural cycle proportion,proportion of two operations,the number of≥18 mm follicles,the age,body mass index,endometrial thickness of operating day,infertility years,number of sperm injected into the uterine cavity,does of Gn,the rate of clinical pregnancy,the rate of abortion and the rate of live birth between the two groups(P>0.05),but anti-mullerian hormone between the two groups was significant differences(P<0.05).Multivariate binary logistic regression model showed that 25(OH)D_(3)was not an independent factor affecting clinical pregnancy.Conclusion There was no correlation between serum 25(OH)D_(3)and clinical pregnancy outcome after AID.Age can be used as good indicator to predict the success rate of AID.

关 键 词：25羟基维生素D_(3) 供精人工授精 临床妊娠结局 

分 类 号：R714[医药卫生—妇产科学]