恒古骨伤愈合剂联合塞来昔布对腰椎间盘突出症术后的作用效果  

Effect of Henggu Bone Injury Healing Agent Combined with Celecoxib on Postoperative Lumbar Disc Herniation

作　　者：姚佩恒 孙志伟 曹飞 姜宁 苗晋军 闫戈 YAO Peiheng;SUN Zhiwei;CAO Fei;JIANG Ning;MIAO Jinjun;YAN Ge(Orthopedics,Henan Rongjun Hospital,Xinxiang 453400,China;Pathology Department,Henan Rongjun Hospital,Xinxiang 453400,China)

机构地区：[1]河南省荣军医院骨科,河南新乡453400 [2]河南省荣军医院病理科,河南新乡453400

出　　处：《河南医学研究》2024年第4期739-743,共5页Henan Medical Research

摘　　要：目的探究恒古骨伤愈合剂联合塞来昔布对腰椎间盘突出症术后的作用效果。方法选取医院2021年2月至2022年12月收治的腰椎间盘突出症并于医院接受手术的86例患者作为研究对象。依照随机数字表法分为实施塞来昔布治疗的对照组和加以恒古骨伤愈合剂干预的研究组,各43例。比较两组的治疗效果、疼痛评分、C反应蛋白(CRP)、白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)水平、腰部功能障碍评分及不良反应。结果研究组总有效率(95.35%)高于对照组(81.40%)(P<0.05)。两组干预前的疼痛评分、血清CRP、IL-6、TNF-α水平、前列腺素E_(2)、5-羟色胺比较差异无统计学意义(P>0.05),干预3个月后,两组疼痛评分、血清CRP、IL-6、TNF-α、前列腺素E_(2)、5-羟色胺水平降低,且研究组低于对照组(P<0.05)。两组干预前腰部功能障碍评分比较差异无统计学意义(P>0.05),干预3个月后两组腰部功能障碍评分升高,且研究组大于对照组(P<0.05)。两组不良反应总发生率相比,差异无统计学意义(P>0.05)。结论恒古骨伤愈合剂联合塞来昔布能够增强治疗效果,减轻腰椎间盘突出症术后神经病理性疼痛,改善腰部功能,减轻炎症反应,且不会增加不良反应,相对安全。Objective To investigate the effect of Henggu bone injury healing agent combined with celecoxib on postoperative lumbar disc herniation.Methods Eighty-six patients with lumbar disc herniation who underwent surgery in the hospital from February 2021 to December 2022 were selected for this study.The patients were divided into a control group treated with celecoxib and a study group treated with Henggu bone healing agent according to the random number table method.With 43 patients in each group.The two groups were compared in terms of effectiveness,pain scores,levels of C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),as well as lumbar dysfunction score and adverse effects.Results The study group’s total effective rate(95.35%)was higher than that(81.40%)in the control group(P<0.05).Before the intervention,there was no statistical difference in the two groups’pain scores,the levels of CRP,IL-6,TNF-α,prostaglandin E_(2)and 5-hydroxytryptamine(P>0.05).After three months of intervention,there was a statistically difference between the two group in pain scores,the levels of CRP,IL-6,TNF-α,prostaglandin E_(2)and 5-hydroxytryptamine,and the study group were lower than those in the control group(P<0.05).Before the intervention,There was no statistical difference in waist dysfunction scores between the two groups(P>0.05),and the waist dysfunction scores of the two groups after 3 months of intervention was improved,and the study group was higher(P<0.05).The incidence of adverse responses of the two groups was not statistically significant(P>0.05).Conclusion Henggu bone injury healing agent combined with celecoxib can enhance the therapeutic effect,reduce neuropathic pain after lumbar disc herniation,improve lumbar function,reduce inflammation,and will not increase adverse reactions,relatively safe.

关 键 词：恒古骨伤愈合剂 腰椎间盘突出症 神经病理性疼痛 炎症 

分 类 号：R682.3[医药卫生—骨科学]