甲硝唑凝胶联合益生菌治疗细菌性阴道炎的疗效及对阴道微环境的影响  

Efficacy of Metronidazole Gel Combined with Probiotics in the Treatment of Bacterial Vaginitis and its Effect on Vaginal Microenvironment

作　　者：黄海燕 HUANG Hai-yan(Department of Obstetrics and Gynecology,Guixi Maternal and Child Health Hospital,Guixi 335400,Jiangxi,China)

机构地区：[1]贵溪市妇幼保健院妇产科,江西贵溪335400

出　　处：《医学信息》2024年第5期134-137,共4页Journal of Medical Information

摘　　要：目的 探究甲硝唑凝胶联合益生菌治疗细菌性阴道炎(BV)的临床疗效及对阴道微环境的影响。方法 收集2019年11月-2022年11月贵溪市妇幼保健院收治的60例BV患者,按照随机数字表法分为对照组与观察组,各30例。对照组给予甲硝唑凝胶治疗,观察组在其基础上联合益生菌治疗,比较两组临床疗效、症状改善情况(外阴瘙痒、阴道灼热、鱼腥臭味、白带异常)、阴道微环境(阴道pH值、阴道分泌物Nugent评分)、阴道清洁度及复发情况。结果 观察组总有效率高于对照组(P<0.05);观察组症状缓解时间(外阴瘙痒、阴道灼热、鱼腥臭味、白带异常)短于对照组(P<0.05);两组治疗后阴道pH值、Nugent评分均低于治疗前,且观察组阴道pH值、Nugent评分低于对照组(P<0.05);两组治疗后阴道清洁度正常率均高于治疗前,且观察组阴道清洁度正常率高于对照组(P<0.05);治疗后3个月,观察组复发率低于对照组(P<0.05)。结论 甲硝唑凝胶联合益生菌治疗细菌性阴道炎疗效确切,可加快症状缓解,改善阴道微环境与清洁度,降低患者的复发率。Objective To investigate the clinical efficacy of metronidazole gel combined with probiotics in the treatment of bacterial vaginitis(BV)and its effect on vaginal microenvironment.Methods A total of 60 BV patients admitted to Guixi Maternal and Child Health Hospital from November 2019 to November 2022 were collected and divided into control group and observation group according to random number table method,with 30 patients in each group.The control group was treated with metronidazole gel,and the observation group was treated with probiotics on the basis of the control group.The clinical efficacy,symptom improvement(vulva pruritus,vaginal burning,fishy odor,abnormal leucorrhea),vaginal microenvironment(vaginal pH value,vaginal secretion Nugent score),vaginal cleanliness and recurrence were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).The symptoms relief time(vulva pruritus,vaginal burning,fishy odor,abnormal leucorrhea)in the observation group were shorter than those in the control group(P<0.05).After treatment,the vaginal pH value and Nugent score of the two groups were lower than those before treatment,and the vaginal pH value and Nugent score of the observation group were lower than those of the control group(P<0.05).The normal rate of vaginal cleanliness in the two groups after treatment was higher than that before treatment,and the normal rate of vaginal cleanliness in the observation group was higher than that in the control group(P<0.05).At 3 months after treatment,the recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusion Metronidazole gel combined with probiotics is effective in the treatment of bacterial vaginitis,which can accelerate symptom relief,improve vaginal microenvironment and cleanliness,and reduce the recurrence rate of patients.

关 键 词：细菌性阴道炎 甲硝唑凝胶 益生菌 阴道微环境 阴道清洁度 

分 类 号：R711.31[医药卫生—妇产科学]