超声造影鉴别直径≥1 cm胆囊病变良恶性的价值分析  

Value of contrast-enhanced ultrasound in differentiating benign and malignant gallbladder lesions which diameter more than 1 cm

作　　者：冯梅晶 任新平 詹维伟[1,2] 郑丽丽 李军建[1] FENG Meijing;REN Xinping;ZHAN Weiwei;ZHENG Lili;LI Junjian(Department of Ultrasound,Xinrui Hospital of Xinwu District,Wuxi(Wuxi Branch of Ruijin Hospital,Shanghai Jiao Tong University School of Medicine),Jiangsu Wuxi 214028,China;Department of Ultrasound,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]江苏省无锡市新吴区新瑞医院(上海交通大学医学院附属瑞金医院无锡分院)超声科,江苏无锡214028 [2]上海交通大学医学院附属瑞金医院超声科,上海200025

出　　处：《外科理论与实践》2023年第6期556-562,共7页Journal of Surgery Concepts & Practice

摘　　要：目的:探讨超声造影,即对比增强超声(contrast-enhanced ultrasound,CEUS)对于鉴别直径≥1 cm胆囊病变良、恶性的价值。方法:对经手术病理确诊、增强CT/MRI检查或随访2年以上临床诊断的142个直径≥1 cm胆囊病变的CEUS资料,进行回顾性分析,总结直径1 cm以上胆囊良、恶性病变的CEUS特性,参考胆囊CEUS相关指南标准计算鉴别胆囊病变良、恶性诊断效能,并将CEUS标准分别与造影剂35 s前消退、60 s前消退联合,计算相应的诊断效能。结果:恶性组CEUS增强模式、增强开始时间、增强消退时间、胆囊壁连续性等方面与良性组比较,差异均有统计学意义(P<0.001)。良、恶性组总体增强水平的差异有统计学意义(P<0.001)。依据CEUS标准诊断胆囊恶性病变的灵敏度93.0%、特异度83.8%、准确率86.6%。CEUS标准联合造影剂35 s前消退诊断胆囊恶性病变的灵敏度、特异度、准确率上升至93.0%、92.9%、93.0%。结论:CEUS鉴别直径≥1 cm胆囊病变良、恶性有较高价值,结合35 s前造影剂消退有助于提高鉴别胆囊病变良恶性的能力。Objective To investigate the clinical value of contrast⁃enhanced ultrasound(CEUS)in differential diagnosis between benign and malignant gallbladder lesions which diameter more than 1 cm.Methods A retrospective analysis included CEUS data of 142 cases with gallbladder lesions diameter more than 1 cm.All lesions were confirmed by surgical pathology,enhanced CT/MRI or clinical diagnosis with following up more than 2 years.To summarize the CEUS characteristics of benign and malignant gallbladder lesions over 1 cm in diameter,the CEUS characteristics of benign and malignant gallbladder lesions diameter more than 1 cm were analyzed,referring to the gallbladder CEUS guidelines.The contrast medium washout before 35 s and 60 s were used as the combined diagnosis with CEUS standard to identify gallbladder cancer,and the diagnostic efficiency was calculated respectively.Results There were statistical differences between the malignant group and the benign group in terms of CEUS enhancement pattern,contrast arrival time,washout time,and gallbladder wall continuity,as well as enhancement levels(P<0.001).The sensitivity,specificity,accuracy in the diagnosis of gallbladder malignant lesions were 93.0%,83.8%,and 86.6%based on CEUS standard.The sensitivity,specificity and accuracy of diagnosis gallbladder malignant lesions were increased to 93.0%,92.9%and 93.0%when combined with washout before 35 s of contrast medium.Conclusions CEUS is highly valuable in differentiating benign and malignant gallbladder lesions diameter more than 1 cm.Combined with contrast medium washout before 35 s is helpful to improve the ability of differentiating benign and malignant gallbladder lesions.

关 键 词：超声造影 胆囊病变 胆囊癌 增强模式 鉴别诊断 

分 类 号：R657.4[医药卫生—外科学] R445.1[医药卫生—临床医学]