女贞子活性成分抗肝纤维化作用机制研究进展  

Research progress on mechanism of active components of Ligustri Lucidi Fructus against hepatic fibrosis

作　　者：叶子雨 何学东 郑永军 李婉婧 曾晴勤 李瑞 刘梦琪 张璟 郑亚东 杨永春 赵金国[4] 宋厚辉 YE Ziyu;HE Xuedong;ZHENG Yongjun;LI Wanjing;ZENG Qingqin;LI Rui;LIU Mengqi;ZHANG Jing;ZHENG Yadong;YANG Yongchun;ZHAO Jinguo;SONG Houhui(Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province,Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics&Advanced Technology,Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management,China-Australia Joint Laboratory for Animal Health Big Data Analytics,College of Animal Science and Technology&College of Veterinary Medicine of Zhejiang A&F University,Hangzhou 311300,China;College of Animal sciences(College of Bee Science),Fujian Agriculture and Forestry University,Fujian-Taiwan Key Laboratory of Animal Pathogen Biology,Fuzhou 350002,China;National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research),NHC Key Laboratory of Parasite and Vector Biology,WHO Collaborating Centre for Tropical Diseases,National Center for International Research on Tropical Diseases,Shanghai 200025,China;Tianshui Province Animal Disease Prevention and Control Center,Tianshui 741000,China)

机构地区：[1]浙江农林大学动物科技学院,动物医学院,浙江省畜禽绿色生态健康养殖应用技术研究重点实验室/动物健康互联网检测技术浙江省工程研究中心,浙江省动物医学与健康管理国际科技合作基地,中澳动物健康大数据分析联合实验室,浙江杭州311300 [2]福建农林大学动物科学学院(蜂学学院)/福建-台湾动物病原生物学重点实验室,福建福州350002 [3]中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心),国家卫生健康委员会寄生虫病原与媒介生物学重点实验室,世界卫生组织热带病合作中心,国家级热带病国际联合研究中心,上海200025 [4]甘肃省天水市动物疫病预防控制中心,甘肃天水741000

出　　处：《中草药》2024年第4期1389-1396,共8页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(32102671);浙江农林大学学生科研训练项目资助(2023KX087)。

摘　　要：肝纤维化为“肝病-肝纤维化-肝硬化/肝癌”的中间环节,存在于大部分肝病的发展过程中。有效逆转肝纤维化是防止其进一步发展的重要手段,但是目前还没有治疗肝纤维化的特效药,而女贞子Ligustri Lucidi Fructus作为一种天然药用植物,其活性成分具有抗肝纤维化功能。通过归纳梳理女贞子活性成分通过调控相关信号通路抗肝纤维化作用机制进行综述,为进一步对女贞子靶向治疗肝纤维化的研究提供理论参考。Hepatic fibrosis(HF)is a middle stage of“liver disease-hepatic fibrosis-cirrhosis/liver cancer”,involved in the development of most liver diseases.To prevent further deterioration of liver disease,effective reversal of HF is an important measure,but currently there is no special-effect drug for the treatment of HF.However,Nvzhenzi(Ligustri Lucidi Fructus),as a natural medicinal plant,has active ingredients with anti-hepatic fibrosis function.By summarizing the mechanism of action of the active ingredients of Ligustri Lucidi Fructus in anti-HF by regulating related signaling pathways,this study provides a theoretical reference for the further research on the targeted treatment of HF by Ligustri Lucidi Fructus.

关 键 词：女贞子 肝纤维化 肝脏星状细胞 细胞信号通路 红景天苷 齐墩果酸 芹菜素 熊果酸 委陵菜酸 

分 类 号：R285[医药卫生—中药学]