Local field potentials,spiking activity,and receptive fields in human visual cortex  

作　　者：Lu Luo Xiongfei Wang Junshi Lu Guanpeng Chen Guoming Luan Wu Li Qian Wang Fang Fang 

机构地区：[1]School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health,Peking University,Beijing 100871,China [2]School of Psychology,Beijing Sport University,Beijing 100084,China [3]Department of Neurosurgery,Sanbo Brain Hospital,Capital Medical University,Beijing 100093,China [4]Beijing Key Laboratory of Epilepsy,Epilepsy Center,Sanbo Brain Hospital,Capital Medical University,Beijing 100093,China [5]IDG/McGovern Institute for Brain Research,Peking University,Beijing 100871,China [6]Peking-Tsinghua Center for Life Sciences,Peking University,Beijing 100871,China [7]Beijing Institute for Brain Disorders,Beijing 100069,China [8]State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research,Beijing Normal University,Beijing 100875,China

出　　处：《Science China(Life Sciences)》2024年第3期543-554,共12页中国科学（生命科学英文版）

基　　金：supported by the National Science and Technology Innovation 2030 Major Program(2022ZD0204802,2022ZD0204804);the National Natural Science Foundation of China(31930053,32171039);Beijing Academy of Artificial Intelligence(BAAI)。

摘　　要：The concept of receptive field(RF) is central to sensory neuroscience. Neuronal RF properties have been substantially studied in animals,while those in humans remain nearly unexplored. Here, we measured neuronal RFs with intracranial local field potentials(LFPs) and spiking activity in human visual cortex(V1/V2/V3). We recorded LFPs via macro-contacts and discovered that RF sizes estimated from lowfrequency activity(LFA, 0.5–30 Hz) were larger than those estimated from low-gamma activity(LGA, 30–60 Hz) and high-gamma activity(HGA, 60–150 Hz). We then took a rare opportunity to record LFPs and spiking activity via microwires in V1 simultaneously. We found that RF sizes and temporal profiles measured from LGA and HGA closely matched those from spiking activity. In sum, this study reveals that spiking activity of neurons in human visual cortex could be well approximated by LGA and HGA in RF estimation and temporal profile measurement, implying the pivotal functions of LGA and HGA in early visual information processing.

关 键 词：human visual cortex receptive field intracranial EEG local field potential spiking activity 

分 类 号：R338.8[医药卫生—人体生理学]