Injectable chitosan hydrogels loaded with antioxidant agent as first-aid dressings for second-degree burn wounds  

作　　者：REN Hui ZHANG Zhen LU KaiLun SHEN YuanYuan HE ChaoLiang CHEN XueSi 

机构地区：[1]CAS Key Laboratoryof Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China

出　　处：《Science China(Technological Sciences)》2024年第3期891-901,共11页中国科学（技术科学英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos. 52173147, 22105198, 51973218, 51833010);the Scientific and Technological Development Projects of Jilin Province(Grant No. 20210204136YY)。

摘　　要：Burn wounds are destructive skin traumas typically of irregular shape and large area. Prone to infection, they require frequent dressing replacement, and painless removal of dressings from burn wounds remains a major challenge. This study focuses on the dynamic characteristics and treatment difficulty of burn wounds. Hydrogel dressings based on glycol chitosan and propionaldehyde-or benzaldehyde-terminated 4-arm poly(ethylene glycol) were designed on the basis of Schiff base cross-linking networks. The hydrogels exhibited shape-adaptability, self-healing and fast-degradation properties, which makes these hydrogels suitable for burn wounds. Salvianolic acid B(SaB)-loaded hydrogel exhibited good antioxidant properties in vitro. In a rat model of deep second-degree burn wounds, the SaB-loaded hydrogel could quickly reduce wound temperature, regulate wound oxidant microenvironment, promote angiogenesis, and accelerate wound healing. Thus, the drug-loaded hydrogel shows significant potential as a first-aid dressing for treatment of burn wounds.

关 键 词：hydrogel dressing fast-degradation shape-adaptability stress relaxation burn wound treatment 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]