羊膜腔内感染微生物分布及相关影响因素分析  

Distribution of microbiota and related infection factors in amniotic cavity infection

作　　者：谭晓霞 刘姣 陈颖 TAN Xiaoxia;LIU Jiao;CHEN Ying(Clinical Laboratory,Lishui Maternal and Child Health Hospital,Lishui,Zhejiang 323000,China;不详)

机构地区：[1]丽水市妇幼保健院检验科,浙江323000

出　　处：《中国微生态学杂志》2024年第1期46-50,共5页Chinese Journal of Microecology

基　　金：丽水市公益性技术应用研究项目(2021GYX30)。

摘　　要：目的研究剖宫产术中产妇的感染症状、羊水微生物分布情况及相关影响因素,为该类患者的治疗提供帮助。方法采集本院2020年6月至2023年2月于剖宫产术中提取的羊水498份进行细菌培养,根据羊水微生物分布情况和相关因素,综合分析产妇临床感染症状。结果498份送检羊水标本中有147份标本检出微生物,总检出率为29.5%(147/498)。498例产妇中有100例术前出现感染症状,检出微生物78株;51例术后出现感染症状,检出微生物34株;8例术后切口感染,检出微生物7株。339例没有临床感染症状的产妇检出微生物28株。羊水微生物的检出率与胎膜早破或试产后人工破膜、产妇自身阴道菌群分布、术前出现感染症状呈显著相关(均P<0.05)。结论对胎膜早破、阴道菌群失调等高危产妇及时送检标本查找病原体,对羊膜腔内感染的早期预防和针对性治疗具有显著意义。Objective To observe the distribution of amniotic fluid microbiota,related infection factors and infection symptoms in postpartum women during cesarean section,providing a reference for the treatment.Methods A total of 498 amniotic fluid samples from our hospital during cesarean section from June 2020 to February 2023 were collected for bacterial culture.Based on the distribution of microbiota in amniotic fluid and the related factors,clinical infection symptoms were comprehensively analyzed.Results In the 498 amniotic fluid samples,147 samples were microorganisms positive,with a total detection rate of 29.5%(147/498).Among the 498 postpartum women,100 had preoperative infection symptoms,and 78 strains of microorganisms were detected;51 cases showed postoperative infection symptoms and 34 strains of microorganisms were detected;8 cases of postoperative incision infection and 7 strains of microorganisms were detected;28 out of 339 postpartum women without clinical infection symptoms were found to be microorganisms positive.The detection rate of microorganisms was related to premature rupture of membranes or artificial rupture of membranes after trial delivery,the distribution of vaginal microbiota,and the occurrence of infection symptoms before surgery(all P<0.05).Conclusion For high-risk pregnant women with premature rupture of membranes and dysbiosis of vaginal microbiota,timely detection of pathogens can provide an effective reference for early prevention and targeted treatment of amniotic cavity infection.

关 键 词：羊水 微生物分布 羊膜腔内感染 阴道菌群 

分 类 号：R446.5[医药卫生—诊断学]