2型糖尿病伴冠心病患者肠道菌群分布及其与糖、脂代谢指标的相关性  

The intestinal flora distribution and its correlation with glucose and lipid metabolism indexes in patients with type 2 diabetes mellitus and coronary heart disease

作　　者：牛尚梅[1] 赵晓玲 李欣欣 NIU Shangmei;ZHAO Xiaoling;LI Xinxin(Department of Endocrinology,the First Hospital of Handan,Handan,Hebei 056002,China;不详)

机构地区：[1]邯郸市第一医院内分泌二科,河北056002

出　　处：《中国微生态学杂志》2024年第1期61-65,70,共6页Chinese Journal of Microecology

基　　金：河北省医学科学研究课题计划项目(20211123)。

摘　　要：目的探讨2型糖尿病伴冠心病患者肠道菌群分布及其与糖、脂代谢指标的关系,为该类患者的治疗提供参考。方法选取2021年1月至2021年12月我院收治的2型糖尿病伴冠心病患者50例作为试验组,选择50例同期在我院体检的健康人作为对照组,比较2组对象基本资料、肠道菌群分布(肠杆菌、肠球菌、双歧杆菌、拟杆菌、乳杆菌)、糖代谢指标[空腹血糖(FPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)]水平、脂代谢指标[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平,分析肠道菌群分布与糖、脂代谢指标的相关性。结果2组对象年龄、性别、体质量指数、收缩压、舒张压、吸烟史、高血压史比较差异均无统计学意义(均P>0.05)。试验组患者肠道肠杆菌、肠球菌数量均高于对照组,双歧杆菌、拟杆菌、乳杆菌数量均低于对照组(均P<0.05)。试验组患者FPG、FINS、血清HbA1c水平均高于对照组(均P<0.05)。试验组患者血清TC、TG、LDL-C水平均高于对照组,而血清HDL-C水平低于对照组(均P<0.05)。试验组患者肠道肠杆菌、肠球菌与FPG、HbA1c、FINS、TC、TG、LDL-C水平均呈正相关,与HDL-C均呈负相关(均P<0.05);而肠道双歧杆菌、拟杆菌、乳杆菌与FPG、HbA1c、FINS、TC、TG、LDL-C均呈负相关,与HDL-C均呈正相关(均P<0.05)。结论2型糖尿病伴冠心病患者肠道肠杆菌、肠球菌数量升高,双歧杆菌、拟杆菌、乳杆菌数量降低,且肠道菌群数量与糖、脂代谢指标具有显著相关性。Objective To explore the relationship between intestinal flora distribution and glucose and lipid metabolism indexes in type 2 diabetes mellitus(T2DM)patients with coronary heart disease(CHD),providing a reference for the treatment.Methods Fifty patients with T2DM and CHD treated in our unit from January to December 2021 were selected as the observation group,and 50 healthy individuals who underwent physical examination in our unit during the same period were selected as the control group.The basic data,intestinal flora(Enterobacterium,Enterococcus,Bifidobacterium,Bacteroides,Lactobacillus)distribution,glucose metabolism indexes[fasting blood glucose(FPG),glycated hemoglobin(HbA1c)],fasting insulin(FINS),and lipid metabolism indexes[triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)]were compared between the two groups.The correlation between intestinal flora distribution and glucose and lipid metabolism indexes was analyzed.Results There were no differences in age,sex,body mass index,systolic blood pressure,diastolic blood pressure,disease course,smoking history and hypertension history between the two groups(all P>0.05).The levels of Enterobacter and Enterococcus in the observation group were higher,while those of Bifidobacterium,Bacteroides and Lactobacillus were lower than those in the control group respectively(all P<0.05).The FPG,FINS and serum HbA1c in the observation group were higher than those in the control group(all P<0.05).The serum levels of TC,TG and LDL-C in the observation group were higher,and that of HDL-C was lower than those in the control group,respectively(all P<0.05).Enterobacterium and Enterococcus were positively correlated with FPG,HbA1c,FINS,TC,TG and LDL-C,and negatively correlated with HDL-C(all P<0.05).Bifidobacterium,Bacteroides and Lactobacillus were negatively correlated with FPG,HbA1c,FINS,TC,TG and LDL-C,and positively correlated with HDL-C(all P<0.05).Conclusion In T2DM patients with coronary heart dise

关 键 词：肠道菌群 2型糖尿病 冠心病 糖脂代谢 

分 类 号：R587.1[医药卫生—内分泌]