2007-2022年甘肃省天祝藏族自治县中央补助地方棘球蚴病防治项目实施效果评价  

Effectiveness of the central government⁃funded echinococcosis control programme in Tianzhu Tibetan Autonomous County,Gansu Province from 2007 to 2022

作　　者：李玉花 张鹏 孙晨清 肖宁 杨元成 种宝林 方春 魁国香 刘子婧 李凡[3] 杨诗杰 冯宇[3] LI Yuhua;ZHANG Peng;SUN Chenqing;XIAO Ning;YANG Yuancheng;ZHONG Baolin;FANG Chun;KUI Guoxiang;LIU Zijing;LI Fan;YANG Shijie;FENG Yu(Tianzhu Tibetan Autonomous County Center for Disease Control and Prevention,Wuwei,Gansu 733200,China;National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research),Na-tional Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,National Health Commission Key Laboratory on Parasite and Vector Biology,WHO Centre for Tropical Diseases,National Center for International Research on Tropical Diseas-es,Ministry of Science and Technology,Shanghai 200025,China;Gansu Center for Disease Control and Prevention,Lanzhou,Gansu 730000,China)

机构地区：[1]甘肃省武威市天祝藏族自治县疾病预防控制中心,甘肃天祝733200 [2]中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)、传染病溯源预警与智能决策全国重点实验室、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室、WHO热带病合作中心、科技部国家级热带病国际研究中心,上海200025 [3]甘肃省疾病预防控制中心,甘肃兰州730000

出　　处：《中国血吸虫病防治杂志》2023年第6期626-632,共7页Chinese Journal of Schistosomiasis Control

基　　金：国家重点研发计划(2021YFC2300800,2021YFC2300804)。

摘　　要：目的评价2007—2022年甘肃省天祝藏族自治县中央补助地方棘球蚴病防治项目实施效果,为进一步控制棘球蚴病疫情提供参考。方法2007—2022年,于甘肃省天祝藏族自治县采用多阶段整群随机抽样法抽取部分行政村作为调查点,对12岁及以上居民进行棘球蚴病筛查;以学校为单位对12岁以下儿童进行整群抽样,对抽中学校所有学生进行棘球蚴病筛查;采用系统随机抽样法抽取养犬户,每户采集1份家犬粪便,并于村庄外采集流浪犬粪便样本,以酶联免疫吸附实验检测家犬及流浪犬粪便棘球绦虫抗原;于该县定点屠宰场,对绵羊和牛等家畜进行棘球蚴病筛查。采用Cochran⁃Armitage趋势检验对人群和家畜棘球蚴病检出率以及犬粪便棘球绦虫抗原阳性率进行趋势分析。2007—2022年,随机抽取棘球蚴病筛查对象进行棘球蚴病防治相关知识知晓率调查。结果2007—2022年,甘肃省天祝藏族自治县累计开展12岁及以上人群棘球蚴病筛查290356人·次,发现细粒棘球蚴病患者1094人,12岁及以上居民棘球蚴病检出率呈逐年下降趋势(χ^(2)=358.602,P<0.001)。2007—2022年,天祝藏族自治县累计开展12岁以下儿童棘球蚴病筛查32931人·次,发现棘球蚴病患儿296人,儿童棘球蚴病检出率呈逐年下降趋势(χ^(2)=267.673,P<0.001)。2007—2022年,天祝藏族自治县累计检测家犬粪便样本33230份,发现棘球绦虫抗原阳性1777份,家犬粪便棘球绦虫抗原阳性率呈下降趋势(χ^(2)=2210.428,P<0.001),但2016—2022年家犬粪便棘球绦虫抗原阳性率呈上升趋势(χ^(2)=37.745,P<0.001)。2019—2022年,天祝藏族自治县流浪犬粪便棘球绦虫抗原阳性率未发现升高或降低趋势(χ^(2)=0.315,P=0.575)。2007—2022年,天祝藏族自治县累计开展绵羊棘球蚴病筛查10973只,发现棘球蚴病病羊334只,绵羊棘球蚴病检出率呈下降趋势(χ^(2)=53.579,P<0.001),但2015—2022年检出率未发现升高或�Objective To evaluate the effectiveness of the central government⁃funded echinococcosis control programme in Tianzhu Tibetan Autonomous County,Gansu Province from 2007 to 2022,so as to provide insights into echinococcosis control.Methods Administrative villages were sampled using a multi⁃stage cluster random sampling method from Tianzhu Tibetan Au⁃tonomous County,Gansu Province from 2007 to 2022,and all residents at ages of 12 years and older in the sampled villages were screened for echinococcosis,and schools were sampled using a cluster sampling method,and all children at ages of 12 years and older in the sampled schools were screened for echinococcosis.Domestic dogs were sampled using a systematic random sampling method,and one domestic dog stool sample was collected from each household.Stray dog stool samples were collected outside the villages,and Echinococcus coproantigens were detected using enzyme⁃linked immunosorbent assay in domestic and stray dogs.In addition,echinococcosis was screened in sheep and cattle in designated slaughterhouses in Tianzhu Tibetan Autonomous County.The trends in the prevalence of echinococcosis in humans and livestock and the positive rate of Echinococcus coproantigens in dogs were examined with the Cochran⁃Armitage trend test.In addition,individuals screened for echinococcosis were randomly sampled from 2007 to 2022 for survey on the awareness of echinococcosis control knowledge.Results A total of 290356 person⁃times were screened for echinococcosis among residents at ages of 12 years and older in Tianzhu Tibetan Autonomous County,Gansu Province from 2007 to 2022,with 1094 residents detected with cystic echinococcosis,and the detection of echinococcosis appeared a tendency towards a gradual decline over years(χ^(2)=358.602,P<0.001).A total of 32931 person⁃times were screened for echinococcosis among children at ages of 12 years and older in Tianzhu Tibetan Autonomous County,Gansu Prov⁃ince from 2007 to 2022,with 296 children detected with echinococcosis,and the

关 键 词：棘球蚴病 综合防治 效果评价 天祝藏族自治县 

分 类 号：R532.32[医药卫生—内科学]