Study on Antibacterial Activity of 2-Methyl-3-(methylthio)Pyrazine Against Three Strains of Spoilage Bacteria  

作　　者：Kun LI Guanghe ZHU Danning FU Lele LI 

机构地区：[1]School of Medicine,Huanghe Science and Technology University,Zhengzhou 450063,China

出　　处：《Agricultural Biotechnology》2024年第1期74-77,共4页农业生物技术（英文版）

基　　金：Supported by The Tackling-plan Project of Henan Department of Science and Technology (222102310388);Key Scientific Research Plan of Colleges in Henan Province (22B350002);Henan Provincial Medical Science and Technology Research Plan Joint Construction Project (LHGJ20191520).

摘　　要：Previous studies have shown that glycine and proline are pharmacophores that display antibacterial activity.In the present study,glycine and proline were derivated to diketopiperazine compounds by chemical synthesis method,and their antibacterial activities were evaluated by three strains of spoilage bacteria,Escherichia coli,Pseudomonas aeruginosa and Shewanella putrefaciens,and the relationship of their antibacterial activities and structures was also investigated.Uv-vis spectrophotometry was used to determine the growth curves of three kinds of active indicator bacteria.Minimum inhibitory concentration(MIC)was determined by micro broth dilution method.The results showed that 2-methyl-3-(methylthio)pyrazine had significant antibacterial activity against three strains of the bacteria,and its MIC was 1.25%.It indicates 2-methyl-3-(methylthio)pyrazine has the potential to be developed as a kind of preservative in future.

关 键 词：2-Methyl-3-(methylthio)pyrazine Growth curve Minimum inhibitory concentration 

分 类 号：S436.34[农业科学—农业昆虫与害虫防治]