基于古今医案云平台探讨齐元富从癌毒论治大肠癌的用药经验  

Exploring Professor QI Yuanfu's Experience in Treating Colorectal Cancer from Cancer Toxicity Based on the Ancient and Modern Medical Case Cloud Platform

作　　者：张杰翔 袁伟琛 夏蕾[3] 齐元富[3] ZHANG Jiexiang;YUAN Weichen;XIA Lei;QI Yuanfu(Shandong University of Traditional Chinese Medicine,Ji'nan Shandong 250014,China;Nanjing University of Chinese Medicine,Nanjing Jiangsu 210023,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji'nan Shandong 250014,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]南京中医药大学,江苏南京210023 [3]山东中医药大学附属医院,山东济南250014

出　　处：《中医药导报》2024年第2期89-93,122,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：山东省2019-2020年度中医药科技发展计划项目(2019-0067);齐元富山东省名老中医药专家传承工作室(2019)。

摘　　要：目的:探讨齐元富教授从癌毒论治大肠癌的用药经验和学术思想。方法:收集齐元富教授治疗大肠癌的处方并建立数据库,运用古今医案云平台中的频数、功效、性味、归经、关联规则、层次聚类、复杂网络分析模块进行数据挖掘。结果:共纳入214份处方,共137味中药。高频药物为柴胡、重楼、陈皮、清半夏、党参,功效多为燥湿化痰、清热解毒、升举阳气,药性多为温、微寒、平,药味多为苦、辛、甘,归经多为肝、脾、肺经。关联规则分析出柴胡、重楼、陈皮、清半夏、党参、生甘草的两两配伍组合,聚类分析出5个组方,复杂网络分析出11味核心中药。结论:齐元富教授认为大肠癌的病因病机为脾胃虚弱、气机郁滞、癌毒兼夹痰湿瘀血,临床须以益气健脾、调达气机、燥湿化痰、清热解毒4种基本治法为主,并联合辨证与辨症论治。Objective:To explore professor QI Yuanfu's experience and academic thoughts in treating colorectal cancer from the theory of cancer toxicity.Methods:Professor QI Yuanfu's prescriptions for treating colorectal cancer were collected and a database was established.And data mining was performed using the frequency,efficacy,nature and flavor,meridian distribution,association rules,hierarchical clustering,and complex network analysis modules in the Ancient and Modern Medical Case Cloud platform.Results:A total of 214 prescriptions with 137 Chinese medicines were included.The high-frequency drugs were Chaihu(radix bupleuri),Chonglou(Paris polyphylla),Chenpi(pericarpium citri reticulatae),Qingbanxia(Rhizoma Pinelliae Preparata)and Dangshen(Codonopsis pilosula),and effect were mostly drying dampness and resolving phlegm,clearing heat and detoxifying toxins,and raising Yang Qi.Herb nature were mostly warm,slightly cold and plain,and herb flavor were mostly bitter,pungent and sweet.In terms of meridian distribution,liver,spleen and lung liver meridians were the most critical.The association rule analysis determined the pairwise combination of of Chaihu(radix bupleuri),Chonglou(Paris polyphylla),Chenpi(pericarpium citri reticulatae),Qingbanxia(Rhizoma Pinelliae Preparata),Dangshen(Codonopsis pilosula)and Shenggancao(Radix glycyrrhizae).A total of five clustering combinations were formed based on clustering analysis,and complex network analysis identified 11 core herbs.Conclusion:Professor QI Yuanfu concludes that the etiology and pathogenesis of colorectal cancer are weakness of the spleen and stomach,stagnation of the Qi mechanism,and cancer toxicity with phlegm,dampness and stagnation of blood,and that the clinical treatment should be based on the four basic methods of benefiting the Qi and strengthening the spleen,regulating the Qi mechanism,drying dampness and resolving phlegm,and clearing heat and detoxifying the toxin,together with the identification of syndromes and symptoms.

关 键 词：大肠癌 古今医案云平台 癌毒 数据挖掘 齐元富 用药经验 

分 类 号：R273[医药卫生—中西医结合]