从胰腺脂肪组织探讨针刺改善糖脂代谢病的免疫代谢机制  

Immune metabolic mechanisms of acupuncture in improving glycolipid metabolic disorders explored through pancreatic adipose tissue

作　　者：刘芸[1] 余芝[1] 夏有兵[1,2] 徐斌 徐天成[1] LIU Yun;YU Zhi;XIA Youbing;XU Bin;XU Tiancheng(Key Laboratory of Integrated Acupuncture and Medicine Research of Ministry of Education,Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu Province,China;College of Medical Information&Engineering,Xuzhou Medical University)

机构地区：[1]南京中医药大学针药结合教育部重点实验室,江苏南京210023 [2]徐州医科大学医学信息与工程学院

出　　处：《中国针灸》2024年第3期333-337,共5页Chinese Acupuncture & Moxibustion

基　　金：国家自然科学基金青年科学基金项目:82305376;国家自然科学基金面上项目:81873238、82074532;2023年江苏省研究生科研与实践创新计划项目:KYCX23_2209。

摘　　要：胰腺脂肪组织是糖脂代谢病发展的重要结构基础,了解胰腺脂肪浸润的发生机制及调节策略有助于早期干预糖脂代谢病。胰腺脂肪组织是联系全身免疫代谢的重要介质,胰腺血管系统则是感知胰腺免疫反应及机体能量稳态的新靶点,共同参与糖脂代谢病发展。针刺具有调控胰腺常驻巨噬细胞与胰腺脂肪细胞间互作的潜在效应,可逆转胰腺脂肪过度蓄积,其作用具有血管依赖性。Pancreatic adipose tissue serves as a crucial structural basis for the development of glycolipid metabolic disorders.Understanding the mechanisms underlying pancreatic adipose tissue infiltration and regulatory strategies is essential for early intervention in glycolipid metabolic disorders.Pancreatic adipose tissue functions as a significant medium linking systemic immune metabolism,while the pancreatic vascular system emerges as a novel target for sensing pancreatic immune responses and maintaining the body's energy homeostasis,collectively participating in the development of glycolipid metabolic disorders.Acupuncture possesses potential effects in modulating the interaction between resident macrophages and adipocytes in the pancreas,leading to the reversible reduction of excessive pancreatic adipose accumulation,with its action being vascular-dependent.

关 键 词：糖脂代谢病 胰腺脂肪组织 针刺 免疫代谢 

分 类 号：R245[医药卫生—针灸推拿学]