黄鹤汤治疗肺脾气虚型变应性鼻炎的疗效观察  

Clinical observation on the therapeutic effect of Huanghe Decoction on allergic rhinitis

作　　者：樊永将 黄卫[2] 章如新 郝亚楠[2] FANG Yongjiang;HUAN Gwei;ZHANG Ruxin;HAO Yanan(Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China)

机构地区：[1]上海中医药大学,201203 [2]上海中医药大学附属第七人民医院耳鼻咽喉科 [3]复旦大学附属华东医院耳鼻咽喉科,上海

出　　处：《中国中西医结合耳鼻咽喉科杂志》2024年第1期16-23,共8页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：上海浦东新区中医薄弱学科建设-耳鼻咽喉科(PDZY-2020-0401)。

摘　　要：目的 观察黄鹤汤治疗肺脾气虚型变应性鼻炎的临床疗效。方法 肺脾气虚型变应性鼻炎患者177例,随机分为西药治疗组59例、中药治疗组60例和联合用药组58例。西药组予氯雷他定口服,中药组予黄鹤汤口服,联合用药组同时给予黄鹤汤及氯雷他定口服。均以14天为1疗程,连续用药3疗程。疗程结束后,所有患者均随访1年。同时,分别于治疗开始前、疗程结束时及随访期结束时检测血清Ig E以及细胞因子IL-4与IFN-γ水平。然后,比较分析各组患者治疗前、治疗后、随访期的临床症状评分及总有效率,以及各组血清Ig E及细胞因子IL-4,IFN-γ水平的变化趋势。结果 治疗结束时,西药治疗组总有效率52.5%,中药治疗组总有效率71.6%,联合治疗组为93.1%,差异具有显著性统计学意义(P<0.05)。随访期结束时,西药组总有效率37.2%,中药组总有效率58.3%,联合治疗组总有效率82.7%,中药组及联合用药组远期疗效均优于西药组(P<0.05)。中药组及联合用药组Ig E及IL-4降低水平、IFN-γ提升效率均优于西药组(P<0.05)。三组的药物不良反应差异均无统计学意义(P>0.05)。结论 黄鹤汤治疗肺脾气虚型变应性鼻炎疗效确切,联合应用抗组胺药会进一步提升疗效水平且无明显毒副作用。Objective To evaluate the therapeutic efficacy of Huanghe Decoction(HHD) on patients with allergic rhinitis in the pattern of Lung-Spleen Qi Deficiency(LSQD) in a comparative way and to evaluate its pharmacodynamic effects on the serum levels of some cytokines and Ig E.Method A total of 177 patients with allergic rhinitis in the pattern of LSQD were randomly divided into chemical drug treating group(CDTG),herbal medicine treating group(HMTG) and a group treated by a combined therapy with the chemical drug and herbal medicine simultaneously(CTG),with 59,60 and 58 cases in each respectively.Cases in CDTG were treated by loratadine orally taken,ones in HMTG received the treatment by orally taken HHD,and those in CTG received a combined therapy with HHD and loratadine at the same time,all being treated for 14 days as one therapeutic course and given three courses continuously in total.All these cases were followed up for one year after the therapeutic courses ended.At the same time,determined among all these cases were the serum levels of antibody Ig E as well as cytokines IL-4 and IFN-γ at the time points before treatment,by the ends of therapeutic course and following up period respectively.Then,comparatively analyzed were the scores of clinical symptoms and the changed tendencies of Ig E,IL-4 and IFN-γ at the time points before treatment,and by the ends of therapeutic course and following up period respectively,with the total effective rates analyzed at the latter two time points among these three groups of patients as well.Result By the end of therapeutic courses,the total effective rate of CDTG was 52.5%,the one of HMTG was 71.6%,and that of CTG was 93.1% respectively,with significantly statistical significance among them(P<0.05).By the end of following up period,the total effective rate of CDTG was 37.2%,the one of HMTG was 58.3%,and that of CTG was 82.7% respectively,with the rates of HMTG and CTG being much higher than that of CTG(P<0.05),especially with the highest rate in CTG.Concerning their effects on s

关 键 词：变应性鼻炎 黄鹤汤 疗效观察 药效学机制 

分 类 号：R276.1[医药卫生—中医五官科学]