粪菌移植在难治性腹泻中的应用进展  

Application and research progress of fecal microbiota transplantation in refractory diarrhea

作　　者：李彤 王宁 王新 Li Tong;Wang Ning;Wang Xin(Xi'an Medical University,Xi'an,Shaanxi 710021,China;Department of Gastroenterology,Tangdu Hospital,Air Force Military Medical University,Xi'an,Shaanxi 710038,China)

机构地区：[1]西安医学院,陕西西安710021 [2]空军军医大学唐都医院消化内科,陕西西安710038

出　　处：《解放军医学杂志》2024年第2期229-235,共7页Medical Journal of Chinese People's Liberation Army

基　　金：空军军医大学第二附属医院IIT临床研究项目(2022XJSXYW-007)。

摘　　要：难治性腹泻在发病时严重影响患者的日常生活及工作,且目前尚无统一的治疗方法。难治性腹泻患者存在不同程度的肠道菌群失调,因此重建肠道微生态系统可能成为治疗该疾病的有效途径。粪菌移植(FMT)作为一种可重建正常肠道菌群的治疗方法,有潜力成为治疗难治性腹泻的有效方法。近年来,FMT已被应用于部分与肠道菌群失调有关的难治性腹泻的治疗,如复发性艰难梭菌感染、炎症性肠病、肠易激综合征等,均取得了较好的疗效,但至今仍有部分问题尚未得到妥善解决。本文就FMT治疗难治性腹泻的作用机制、在各类难治性腹泻中的临床应用进展及目前所面临的问题进行综述。When refractory diarrhea comes on,it greatly affects the life and daily work of patients,and there is no unified treatment.Patients with refractory diarrhea have varying degrees of intestinal flora disorder,so rebuilding the intestinal micro ecosystem may be an effective way to treat refractory diarrhea.Fecal microbiota transplantation(FMT)has the potential to be an effective treatment for refractory diarrhea as a therapy that reconstructs normal intestinal flora.In recent years,FMT has been applied to the treatment of some refractory diarrhea related to intestinal flora imbalance,such as recurrent clostridium difficile infection,inflammatory bowel disease,irritable bowel syndrome,and has achieved good results,but some problems have not been properly solved so far.This article reviews the mechanism of action of FMT in the treatment of refractory diarrhea,its clinical application,research progress and current problems.

关 键 词：粪菌移植 肠道菌群 难治性腹泻 

分 类 号：R442[医药卫生—诊断学]