加味通络方治疗三证合病型急性脑梗死临床观察  

Modified Tongluo Recipe in the Treatment of Acute Cerebral Infarction of Three Syndrome-combined Disease

作　　者：雷源 梁颖愉 许幸仪 杨之源 邹新兰 陈秀慧 LEI Yuan;LIANG Yingyu;XU Xingyi;YANG Zhiyuan;ZOU Xinlan;CHEN Xiuhui(Department of Encephalopathy,Affiliated Hospital of Traditional Chinese Medicine of Guangzhou Medical University,Guangdong Province,Guangzhou 510130,China;Department of Encephalopathy,Yingde Hospital of Traditional Chinese Medicine,Guangdong Province,Qingyuan 513099,China;Department of Encephalopathy,Orthopedic Hospital,Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou 510240,China)

机构地区：[1]广州医科大学附属中医医院脑病科,广东广州510130 [2]英德市中医院脑病科,广东清远513099 [3]广州中医药大学附属骨伤科医院脑病科,广东广州510240

出　　处：《中国中医药现代远程教育》2024年第8期108-110,共3页Chinese Medicine Modern Distance Education of China

基　　金：广东省中医药局科研项目【No.20184017】。

摘　　要：目的观察加味通络方对“三证合病”(气虚血瘀兼阴虚型)型急性脑梗死(ACI)患者血清炎性因子及同型半胱氨酸(Hcy)的影响及临床疗效。方法选取2018年1月—2020年5月广州医科大学附属中医医院脑病科收治的“三证合病”型ACI患者135例,按随机数字表法分为血栓通对照组、通络Ⅳ号方组及加味通络方组,观察三组的患者治疗前后的血清炎性因子、Hcy水平变化。结果三组患者治疗前的血清炎症因子、Hcy水平比较,差异无统计学意义(P>0.05)。治疗后,三组炎症因子、Hcy水平均降低(P<0.05),且加味通络方组及通络Ⅳ号方组的炎症因子、Hcy水平较血栓通组低(P<0.05)。结论对于“三证合病”型ACI患者,在常规治疗基础上加用加味通络方,可缓解炎症反应、降低Hcy水平,进而改善患者的神经功能及提高生活质量。Objective To observe the effect and curative effect of modified Tongluo recipe on serum inflammatory factors and homocysteine in patients with acute cerebral infarction of “three syndrome-combined disease”(qi deficiency,blood stasis and yin deficiency type).Methods From January 2018 to May 2020,a total of 135 patients with acute cerebral infarction with “three-syndrome combined disease” admitted to department of encephalopathy of Affiliated Hospital of Traditional Chinese Medicine of Guangzhou Medical University were selected and divided into Xueshuantong control group,Tongluo Ⅳ recipe group and modified Tongluo recipe group by random number method.The changes of serum inflammatory factors and Hcy(homocysteine) before and after treatment were observed in the three groups.Results There was no significant difference in serum inflammatory factors and Hcy levels before treatment(P>0.05).After treatment,the levels of inflammatory factors and Hcy in the three groups were decreased(P<0.05),and the levels of inflammatory factors and Hcy in the modified Tongluo recipe group and Tongluo recipe Ⅳ group were lower than those in the Xueshuantong control group(P<0.05).Conclusion For patients with acute cerebral infarction of “three-syndrome combined disease” type,modified Tongluo recipe on the basis of conventional treatment can alleviate the inflammatory reaction of patients,reduce the level of homocysteine,and then improve the neurological function and quality of life of patients.

关 键 词：中风 急性脑梗死 气虚血瘀兼阴虚证 加味通络方 三证合病 中医药疗法 

分 类 号：R277.7[医药卫生—中医学]