Research on the Correlation Between rs2110385 Polymorphisms of the Visfatin Gene and Nonproliferative Diabetic Retinopathy  

作　　者：Min Zhang Rong Li Wei-guo Ma Xiao-hong Yin Ya Li 

机构地区：[1]Department of Endocrinology,the First Affiliated Hospital of Xi’an Medical University,Xi’an 710077,Shaanxi Province,China [2]Department of Ophthalmology,the First Affiliated Hospital of Xi’an Medical University,Xi’an 710077,Shaanxi Province,China

出　　处：《Journal of Clinical and Nursing Research》2024年第2期220-227,共8页临床护理研究（英文）

基　　金：Xi’an Science and Technology Bureau Fund(23YXYJ0103);Shaanxi Provincial Science and Technology Department Fund(S2022-YF-YBSF-0939).

摘　　要：Objective:To investigate the association between rs2110385 polymorphisms of the visfatin gene and the risk of type 2 diabetic retinopathy(DR).Methods:172 Han subjects were selected from Xi’an Shaanxi Province;140 patients with type 2 diabetes mellitus(T2DM)and 32 normal controls(NC)were selected from our hospital.Patients with diabetes were divided into a non-DR group(T2DM)(n=69)and a nonproliferative diabetic retinopathy Group(DR)(n=71)after dilated fundus photography and fundus fluorescein angiography.rs2110385/AluⅠgenotypes were detected by standardized polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),and the differences in the detection rates of different genotypes in the above populations were compared.Results:1)The visfatin level in the DR Group was significantly higher than that in the NC and T2DM groups(P<0.05).2)The frequency of GG genotype and G allele of rs2110385 in the DR Group were higher than those in the T2DM and NC groups(80.3,69.6,50.0,86.6,79,65.6,P<0.05).3)There were significant differences in allele frequency and genotype frequency distribution of rs2110385 between the DR Group and the NC group(P<0.01).Conclusion:Visfatin increased in the nonproliferative diabetic retinopathy group and could be a potential indicator for the clinical prediction of DR.The G allele of the rs2110385 polymorphic site may be related to the risk of DR.

关 键 词：VISFATIN Diabetic retinopathy Single nucleotide polymorphism Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) 

分 类 号：R58[医药卫生—内分泌]