基于数据挖掘研究四大儿科典籍治疗小儿慢惊的用药规律  

Research on Medication Rules of Chronic Infantile Convulsion in Four Pediatric Classic Based on Data Mining

作　　者：陈昱 孙珊[1] 罗卉 许俐娜 徐清怡 易鹏飞[1] 陈琳 CHEN Yu;SUN Shan;LUO Hui;XU Lina;XU Qingyi;YI Pengfei;CHEN Lin(Jiangxi Provincial Children's Hospital,Nanchang Jiangxi 330006,China;Nanchang Hongdu Hospital of TCM,Nanchang Jiangxi 330000,China)

机构地区：[1]江西省儿童医院,江西南昌330006 [2]南昌市洪都中医院,江西南昌330000

出　　处：《药品评价》2023年第11期1422-1426,共5页Drug Evaluation

基　　金：江西省中医药管理局科技计划(2020A0304)。

摘　　要：目的运用数据挖掘分析《小儿药证直诀》《活幼心书》《幼科发挥》《幼幼集成》四大经典儿科中医典籍针对小儿慢惊的用药规律。方法收集典籍中关于小儿慢惊风的内服方,建立数据库,利用Microsoft Excel 2021、IBM SPSS Modeler 18.0、IBM SPSS Statistics 25.0等进行药物使用频次分析、功效分析、性味归经分析、关联分析、聚类分析等。结果筛选出处方68首,涉及中药142味,累计用药频次481次。应用频次前三的中药依次为甘草、人参、茯苓,主要为补虚药,主药性为温、平、寒,主药味为辛、甘味,入脾经、心经、肝经、胃经。关联分析置信度最高的三组药为甘草-白芍、甘草-半夏、甘草-陈皮,支持度较高的组合为甘草-人参,甘草-茯苓、人参,茯苓-白术,甘草-陈皮。经聚类分析获得药物组合:麝香、冰片、朱砂、全蝎、僵蚕、防风、天麻,白芍、大枣、肉桂,栀子、黄芩、川芎、当归、泽泻、青皮,木香,天南星、枳壳、茯苓、白术、人参、甘草、陈皮、半夏、桔梗、山药。结论四大儿科典籍治疗小儿慢惊风的用药规律重在理气健脾,调治脾胃,兼顾痉挛抽搐,闭证神昏辅以平肝息风止痉开窍药,兼夹热证痰饮各实证、心烦口溢涎者,予以清热化痰止咳宁心安神药加减。Objective To analyze the medication rules of chronic infantile convulsion in four pediatric classics“Xiao Er Yao Zheng Zhi Jue”,“Huo You Xin Shu”,“You Ke Fa Hui”,“You You Ji Cheng”based on data mining.Methods Collect the oral medication prescriptions related to chronic infantile convulsion and establish a database.Microsoft Excel 2021,IBM SPSS Modeler 18.0,IBM SPSS Statistics 25.0 were used to analyse the using frequency,efficacy,characteristic,taste and conduct association rule analysis and the cluster analysis.Results 68 prescriptions related to chronic infantile convulsion were screened out,involving 142 traditional Chinese medicines,with a cumulative frequency of 481.The top three with the highest frequency of application were licorice,ginseng,and poria cocos.The main efficacy classification drugs were tonifying medicinal.The main properties were warm,neutral and cold.The tastes of the medicine were mainly bitter and sweet.The most relevant meridians were spleen,heart,liver and stomach.The correlation analysis results showed that the three groups of drugs with the highest confidence were licoricewhite peony,licorice-pinellia,and licorice-tangerine peel.The combination with higher support was licorice-ginseng;licoriceporia cocos,ginseng;poria cocos-atractylodes macrocephala and licorice-tangerine peel.Drug combinations were obtained from cluster analysis,including musk,borneol,cinnabar,scorpion,stiff silkworm,saposhnikovia divaricata,gastrodia elata;white peony,jujube,cinnamon;gardenia,scutellaria baicalensis,szechuan lovage rhizome,angelica sinensis,alisma orientalis,citri reticulatae pericarpium viride,aucklandiae radix;arisaema erubescens,arisaema erubescens,poria cocos,atractylodes macrocephala,ginseng,licorice,tangerine peel,pinellia ternata,platycodon grandiflorum,yam.Conclusion The medication rules of chronic infantile convulsion in four pediatric classics attached great importance to regulating the spleen and stomach,supplementing with liverpacifying and wind-extinguishing and orifice-o

关 键 词：慢惊风 慢脾风 数据挖掘 用药规律 《小儿药证直诀》 《活幼心书》 《幼科发挥》 《幼幼集成》 

分 类 号：R272[医药卫生—中医儿科学]