Additive manufactured osseointegrated screws with hierarchical design  

作　　者：Wenbo Yang Hao Chen Haotian Bai Yifu Sun Aobo Zhang Yang Liu Yuchao Song Qing Han Jincheng Wang 

机构地区：[1]Department of Orthopedics,Second Hospital of Jilin University,Changchun 130022,China [2]College of Biological and Agricultural Engineering,Jilin University,Changchun 130022,China [3]School of Materials Science and Engineering,Jilin University,Changchun 130022,China

出　　处：《Bio-Design and Manufacturing》2024年第2期206-235,共30页生物设计与制造（英文）

基　　金：supported by the National Natural Science Foundation of China(Nos.82272504 and 82072456);the National Key R&D Program of China(No.2018YFB1105100);the Department of Science and Technology of Jilin Province,China(Nos.20200404202YY,20200403086SF,20210101321JC,20210204104YY,20200201453JC,20220204119YY,202201ZYTS131,202201ZYTS129,20220401084YY,202201ZYTS505,and YDZJ202301ZYTS076);the Department of Finance of Jilin Province,China(No.2020SCZT037);the Jilin Provincial Development and Reform Commission,China(Nos.2018C010 and 2022C043-5);the Interdisciplinary Integration and Cultivation Project of Jilin University(No.JLUXKJC2020307);the Central University Basic Scientific Research Fund(No.2023-JCXK-04).

摘　　要：Bone screws are devices used to fix implants or bones to bones.However,conventional screws are mechanically fixed with thread and often face long-term failure due to poor osseointegration.To improve osseointegration,screws are evolving from solid and smooth to porous and rough.Additive manufacturing(AM)offers a high degree of manufacturing freedom,enabling the preparation of predesigned screws that are porous and rough.This paper provides an overview of the problems currently faced by bone screws:long-term loosening and screw breakage.Next,advances in osseointegrated screws are summarized hierarchically(sub-micro,micro,and macro).At the sub-microscale level,we describe surface-modification techniques for enhancing osseointegration.At the micro level,we summarize the micro-design parameters that affect the mechanical and biological properties of porous osseointegrated screws,including porosity,pore size,and pore shape.In addition,we highlight three promising pore shapes:triply periodic minimal surface,auxetic structure with negative Poisson ratio,and the Voronoi structure.At the macro level,we outline the strategies of graded design,gradient design,and topology optimization design to improve the mechanical strength of porous osseointegrated screws.Simultaneously,this paper outlines advances in AM technology for enhancing the mechanical properties of porous osseointegrated screws.AM osseointegrated screws with hierarchical design are expected to provide excellent long-term fixation and the required mechanical strength.

关 键 词：Bone screws Additive manufacturing Architecture design Surface modification 

分 类 号：R318[医药卫生—生物医学工程]