甲型流感病毒NP及相关宿主因子研究进展  

Research progress on NP and related host factors of influenza A virus

作　　者：高三利 孙欣 王盛羽 宋鸿 GAO Sanli;SUN Xin;WANG Shengyu;SONG Hong(Department of Microbiology,Zunyi Medical University,Zunyi 563000,Guizhou,China;Key Laboratory of Infectious Diseases and Biosafety in Guizhou Universities of Zunyi Medical University,Zunyi)

机构地区：[1]遵义医科大学微生物学教研室,贵州遵义563000 [2]遵义医科大学贵州省普通高等学校传染病与生物安全特色重点实验室

出　　处：《中国病原生物学杂志》2024年第3期360-366,共7页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.31902283);遵义医科大学博士科研启动资金(No.F-986)。

摘　　要：甲型流感病毒(influenza A virus,IAV)严重威胁人类健康。病毒核心是核糖核蛋白复合物(viral ribonucleoprotein complexes,vRNPs),是病毒基因组转录和复制的最小功能单位。核蛋白(nucleoprotein,NP)是vRNP的重要组成部分之一,在流感病毒整个生命周期起着关键作用。机体存在多种宿主因子通过NP影响病毒增殖。本文就通过NP影响vRNP核输入、病毒基因组转录和复制、vRNP核输出以及vRNP组装这几个方面的宿主因子进行综述,以期为治疗IAV新靶点的发现及新药物的研发提供参考。Influenza A virus(IAV)poses a serious threat to human health.The core of virus is ribonucleoprotein complexes(vRNPs),which are the smallest functional units of the viral genome transcription and replication.Nucleoprotein(NP)is one of the important components of vRNP and plays a key role in entire influenza virus life cycle.There are multiple host factors in body that affect proliferation of virus through NP.In this paper,we review host factors that influence vRNP nuclear import,viral genome transcription and replication,vRNP nuclear export,and vRNP assembly through NP,which provides reference for the discovery of new targets and antiviral drug development.

关 键 词：甲型流感病毒 核蛋白NP 宿主因子 病毒增殖 相互作用 综述 

分 类 号：R373[医药卫生—病原生物学]