伊维菌素抗病毒作用及机制研究进展  

Research progress on antiviral activity and mechanism of Ivermectin

作　　者：王挺 邹振兴[1] 胡永灵[1] WANG Ting;ZOU Zhenxing;HU Yongling(Hunan Polytechnic of Environment and Biology,Hengyang 421005)

机构地区：[1]湖南环境生物职业技术学院,湖南衡阳421005

出　　处：《中国病原生物学杂志》2024年第3期367-370,F0003,共5页Journal of Pathogen Biology

基　　金：湖南省教育厅科学研究项目(No.23C0637);湖南环境生物职业技术学院青年基金项目(No.ZK2021-01)。

摘　　要：伊维菌素广泛应用于寄生虫病的防控,近年来,其广谱抗病毒活性受到了学者的关注。本文系统性梳理了伊维菌素抗病毒研究的相关报道,对其针对疱疹病毒、登革热病毒和新型冠状病毒等抗病毒作用及潜在机制进行总结与分析,发现伊维菌素主要是通过干扰病毒复制阶段发挥抗病毒作用,其抗病毒机制可能为抑制病毒编码蛋白与宿主蛋白结合或抑制病毒编码蛋白入核。本文为伊维菌素的抗病毒研究与应用提供参考。Ivermectin has been widely used in the prevention and control of parasitic disease.In recent years,its broad-spectrum antiviral activates hasattracted wide attention.In this review,the antiviral effects and potential mechanisms of Ivermectin against Herpesvirus,Dengue virus,alphavirus,and SARS-COV-2,etc.were summarized.It was shown that Ivermectin treatment mainly inhibited viral infection via suppressing viral replication,and its antiviral mechanisms were involved in inhibiting the interaction of viral coding proteins with host proteins or inhibiting the entry of viral coding proteins into the nucleus.In summary,this paper has provided a reference for the antiviral research and clinical application of Ivermectin.

关 键 词：伊维菌素 抗病毒活性 作用机制 进展 综述 

分 类 号：R96[医药卫生—药理学]