Eph/Ephrin信号转导途径介导的生物学功能及其相关疾病的研究进展  

Research progress on the biological functions and related diseases mediated by the Eph/Ephrin signal transduction pathways

作　　者：常红敏 朱国强 李传宝[2] Chang Hongmin;Zhu Guoqiang;Li Chuanbao(College of Clinical Medicine,Jining Medical University,Jining 272013,China;Department of Ophthalmology,the Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院临床医学院,272013 [2]济宁医学院附属医院眼科,272029

出　　处：《中华诊断学电子杂志》2024年第1期64-68,共5页Chinese Journal of Diagnostics(Electronic Edition)

基　　金：山东省自然科学基金(ZR2020QH149)。

摘　　要：促红细胞生成素诱导肝细胞(Eph)受体是已知的酪氨酸蛋白激酶受体(RTKs)家族中最大的一类受体,在个体发育过程和多种疾病进程中发挥重要作用。一方面,Eph受体与其膜结合配体(Ephrin)的相互作用介导了胚胎发育到成人的一系列生理和病理过程;另一方面,Eph受体在与病原相关模式分子结合后,可参与机体感染与免疫,促进相关疾病的发生与发展。笔者就近年来Eph/Ephrin信号转导途径介导的生物学功能及相关疾病的最新研究进展进行综述,并总结Eph受体和Ephrin配体在神经系统、血管生成、肿瘤生成以及机体感染与免疫中的作用。Erythropoietin-producing hepatocyte(Eph)receptor is the largest receptors among the known receptor tyrosine kinase(RTKs)family.The Eph receptor plays an important role in human ontogeny and various disease development.On the one hand,the interaction between the Eph receptor and its membrane binding ligand(Ephrin)mediates a range of physiological and pathological processes spanning from embryonic development to adulthood.On the other hand,the Eph receptor can contribute to infection and immunity by binding to pathogen-related model molecules,mediating the occurrence and development of associated diseases.This article reviews the latest research progress on the biological functions and related diseases mediated by the Eph/Ephrin signal transduction pathways in recent years and summarizes the role of the Eph receptor and Ephrin in the nervous system,angiogenesis,tumor development,infection,and immunity.

关 键 词：受体 Eph家族 膜附着型配体 信号转导途径 生物学功能 

分 类 号：R44[医药卫生—诊断学]