中药炮制与用法对药物作用的干预效果  

Intervention effect of traditional Chinese medicine processing and usage on drug action

作　　者：潘延成[1] 张超[1] PAN Yan-cheng;ZHANG Chao(Department of Pharmacy,Tengzhou Central People's Hospital,Tengzhou Shandong Province 277599,China)

机构地区：[1]滕州市中心人民医院药学部,山东滕州277599

出　　处：《中国城乡企业卫生》2024年第1期1-3,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：目的分析中药炮制与用法对药物作用的干预效果,为中药的临床应用提供参考。方法选取2019年11月—2021年12月滕州市中心人民医院收治的200例采取中药治疗的患者为研究对象,随机分为对照组和观察组各100例。对照组患者采用未炮制的中药治疗,观察组采取炮制后的中药治疗,实施的炮制方法主要有净选、切制、纯净、辅制等方法。比较两组临床疗效、不良反应发生率及治疗前后中医证候积分。结果观察组治疗总有效率为98.0%,高于对照组的88.0%,差异有统计学意义(χ^(2)=7.681,P<0.05)。观察组不良反应发生率为1.0%,低于对照组的7.0%,差异有统计学意义(χ^(2)=4.688,P<0.05)。治疗后,观察组中医证候积分为(8.2±1.3)分,低于对照组的(14.0±1.8)分,差异有统计学意义(t=26.122,P<0.05)。结论中药炮制能够提升药性,降低药物毒性,配合合理的用药方法,可在获得较好的临床治疗效果的同时,确保患者用药的安全性。Objective To analyze the intervention effect of traditional Chinese medicine processing and usage on drug action,and provide reference for the clinical application of traditional Chinese medicine.Methods A total of 200 patients treated with traditional Chinese medicine treated in Tengzhou Central People's Hospital from November 2019 to December 2021 were selected as the research subjects and randomly divided into a control group and an observation group,with 100 cases in each group.The control group was treated with unprocessed traditional Chinese medicine,while the observation group was treated with processed traditional Chinese medicine.The processing methods implemented mainly included purifying selection,cutting,purification and auxiliary preparation.The clinical efficacy,incidence of adverse reactions and traditional Chinese medicine syndrome scores before and after treatment between two groups were compared.Results The treatment total effective rate of the observation group was 98.0%,which was higher than 88.0%of the control group,and the difference was statistically significant(χ^(2)=7.681,P<0.05).The incidence of adverse reactions in the observation group was 1.0%,which was lower than 7.0%in the control group,and the difference was statistically significant(χ^(2)=4.688,P<0.05).After treatment,the traditional Chinese medicine syndrome score in the observation group was(8.2±1.3)points,which was lower than that in the control group with(14.0±1.8)points,and the difference was statistically significant(t=26.122,P<0.05).Conclusion Traditional Chinese medicine processing could improve drug properties,reduce drug toxicity,and with reasonable medication use methods,it could achieve good clinical treatment effects while ensuring the safety of patient medication.

关 键 词：中药 炮制方法 药物作用 疗效 不良反应 中医证候积分 

分 类 号：R283[医药卫生—中药学]