三种特应性疾病与斑秃发生风险的因果关系:两样本孟德尔随机化研究  

Causal associations between three atopic diseases and alopecia areata:a two-sample Mendelian randomization study

作　　者：徐媛媛[1,2] 郭玲宏 吴姝玮 张婷 张璐[1,2] 蒋献[1,2] XU Yuanyuan;GUO Linghong;WU Shuwei;ZHANG Ting;ZHANG Lu;JIANG Xian(Department of Dermatology,West China Hospital,Sichuan University,Chengdu 610041,China;Laboratory of Dermatology,Clinical Institute of Inflammation and Immunology,Frontiers Science Center for Disease-related Molecular Network,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院皮肤性病科,四川成都610041 [2]四川大学疾病分子网络前沿科学中心免疫炎症研究院皮肤病学研究室,四川成都610041

出　　处：《中国麻风皮肤病杂志》2024年第4期239-244,共6页China Journal of Leprosy and Skin Diseases

基　　金：四川大学华西医院学科卓越发展1.3.5工程项目(编号:ZYJC21036)。

摘　　要：目的:应用两样本孟德尔随机化分析哮喘、特应性皮炎、过敏性鼻炎与斑秃发生风险之间的因果关系。方法:根据全基因组关联研究的汇总数据集,提取与哮喘、特应性皮炎和过敏性鼻炎显著相关的单核苷酸多态性(single nucleotide polymorphism,SNP)作为工具变量,使用逆方差加权法、MR-Egger回归、加权中位数、简单模型和加权模型评估三种特应性疾病与斑秃之间的因果关联。结果:选取64个、61个、3个分别与哮喘、特应性皮炎、过敏性鼻炎相关的SNP作为工具变量,逆方差加权法证明哮喘、特应性皮炎是斑秃发生的危险因素(OR:1.45;95%CI:1.67~1.97;OR:1.79;95%CI:1.28~2.51);加权中位数和加权模型方法进一步支持因果关联的显著性。结论:哮喘、特应性皮炎与斑秃发病风险之间存在显著的正向因果关系。Objective:To analyze the potential causal associations between three atopic diseases(asthma,atopic dermatitis,and allergic rhinitis)and the risk of developing alopecia areata using two-sample Mendelian randomization.Methods:Summary statistics from the genome-wide jiaoassociation studies(GWAS)were employed.Single nucleotide polymorphisms(SNPs)significantly associated with asthma,atopic dermatitis,and allergic rhinitis were used as instrumental variables.The casual relationship was assessed with five methods:the inverse variance weighted(IVW),MR-Egger regression,weighted median,simple mode and weighted mode methods.The results of analyses were presented with odds ratio and 95%confidence interval.Results:64 SNPs related to asthma,61 SNPs related to atopic dermatitis,and 3 SNPs related to allergic rhinitis were selected as instrumental variables.The IVW method showed that asthma and atopic dermatitis were both risk factors for alopecia areata(OR:1.45,95%CI:1.67-1.97;OR:1.79,95%CI:1.28-2.51),weighted median and weighted mode also supported the significance of causal associations.Conclusion:Mendelian randomization analyses indicated positive causal associations between atopic diseases asthma,atopic dermatitis and alopecia areata.

关 键 词：斑秃 哮喘 特应性皮炎 过敏性鼻炎 孟德尔随机化 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]