皮肤组织常驻记忆T细胞与炎症性皮肤病复发的研究进展  

Update of skin tissue-resident memory T cells and inflammatory skin diseases recurrence

作　　者：陈雪琴 宋志强 CHEN Xueqin;SONG Zhiqiang(Department of Dermatology,the First Affiliated Hospital of Army Medical University,Chongqing 400038,China)

机构地区：[1]陆军军医大学第一附属医院皮肤科,重庆400038

出　　处：《中国麻风皮肤病杂志》2024年第4期292-296,共5页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金(编号:82273529)。

摘　　要：组织常驻记忆T细胞(tissue-resident memory T,T_(RM))是一种新发现的记忆T细胞亚群。在皮肤感染(如HSV、白色念珠菌、利什曼原虫感染)及皮肤肿瘤性疾病(如黑素瘤和鳞状细胞癌)中,皮肤T_(RM)细胞发挥保护作用,在部分自身炎性皮肤病中皮肤T_(RM)细胞起致病作用。本文对皮肤T_(RM)细胞与炎症性皮肤病复发的研究进展进行综述,特别是银屑病、白癜风、特应性皮炎、固定性药疹、斑秃和额部纤维性脱发。Tissue-resident memory T(T_(RM))cells are a newly discovered memory T cell subset.Skin T_(RM)cells play a protective role in skin infections(such as HSV,Candida albicans,and Leishmania infections)and skin neoplastic diseases(such as melanoma and squamous cell carcinoma),and play a pathogeniq role in some autoinflammatory skin diseases.In this paper,we review the update of skin tissue-resident memory T cells and inflammatory skin diseases recurrence,especially psoriasis,vitiligo,atopic dermatitis,fixed drug eruption,alopecia areata and frontal fibrous alopecia.

关 键 词：组织常驻记忆T细胞 银屑病 白癜风 特应性皮炎 固定性药疹 斑秃 额部纤维性脱发 

分 类 号：R751[医药卫生—皮肤病学与性病学]