RCoV19:A One-stop Hub for SARS-CoV-2 Genome Data Integration,Variant Monitoring,and Risk Pre-warning  

作　　者：Cuiping Li Lina Ma Dong Zou Rongqin Zhang Xue Bai Lun Li Gangao Wu Tianhao Huang Wei Zhao Enhui Jin Yiming Bao Shuhui Song 

机构地区：[1]National Genomics Data Center,Beijing Institute of Genomics,Chinese Academy of Sciences and China National Center for Bioinformation,Beijing 100101,China [2]CAS Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences and China National Center for Bioinformation,Beijing 100101,China [3]University of Chinese Academy of Sciences,Beijing 100049,China [4]Sino-Danish College,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Genomics, Proteomics & Bioinformatics》2023年第5期1066-1079,共14页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by grants from the National Key R&D Program of China(Grant Nos.2023YFC3041500 and 2021YFF0703703);the Key Collaborative Research Program of the Alliance of International Science Organizations(Grant No.ANSO-CR-KP-2022-09);the National Natural Science Foundation of China(Grant No.32270718);the Beijing Nova Program(Grant No.Z211100002121006);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant Nos.Y2021038 and 2019104),China.

摘　　要：The Resource for Coronavirus 2019(RCoV19)is an open-access information resource dedicated to providing valuable data on the genomes,mutations,and variants of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).In this updated implementation of RCoV19,we have made significant improvements and advancements over the previous version.Firstly,we have implemented a highly refined genome data curation model.This model now features an automated integration pipeline and optimized curation rules,enabling efficient daily updates of data in RCoV19.Secondly,we have developed a global and regional lineage evolution monitoring platform,alongside an outbreak risk pre-warning system.These additions provide a comprehensive understanding of SARS-CoV-2 evolution and transmission patterns,enabling better preparedness and response strategies.Thirdly,we have developed a powerful interactive mutation spectrum comparison module.This module allows users to compare and analyze mutation patterns,assisting in the detection of potential new lineages.Furthermore,we have incorporated a comprehensive knowledgebase on mutation effects.This knowledgebase serves as a valuable resource for retrieving information on the functional implications of specific mutations.In summary,RCoV19 serves as a vital scientific resource,providing access to valuable data,relevant information,and technical support in the global fight against COVID-19.The complete contents of RCoV19 are available to the public at https://ngdc.cncb.ac.cn/ncov/.

关 键 词：SARS-CoV-2 Mutation VARIANTS Surveillance Pre-warning 

分 类 号：Q811.4[生物学—生物工程] R37[医药卫生—病原生物学]