镁及镁合金植入物在运动医学中的应用研究进展  

Research progress of magnesium and magnesium alloy implants in sports medicine

作　　者：吴雨宽 白浪 刘妍兰 韩潜 刘俏男 艾义翔 徐美光 温暖洋 单智伟 尹战海[1] WU Yukuan;BAI Lang;LIU Yanlan;HAN Qian;LIU Qiaonan;AI Yixiang;XU Meiguang;WEN Nuanyang;SHAN Zhiwei;YIN Zhanhai(Department of Orthopedics,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an Shaanxi,710061,P.R.China;Department of Materials Science and Engineering,Xi’an Jiaotong University,Xi’an Shaanxi,710049,P.R.China;Engineering Research Center for Magnesium-based New Materials,Xi’an Jiaotong University,Xi’an Shaanxi,710049,P.R.China)

机构地区：[1]西安交通大学第一附属医院骨科,西安710061 [2]西安交通大学材料科学与工程学院,西安710049 [3]西安交通大学陕西省镁基新材料工程研究中心,西安710049

出　　处：《中国修复重建外科杂志》2024年第3期380-386,共7页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(82072429);陕西省重点研发计划项目(2020SF-093)。

摘　　要：目的 对镁及镁合金植入物在运动相关损伤修复重建中的应用研究进展进行综述。方法 广泛查阅近年来国内外相关研究文献,对镁及镁合金材料特性和其用于不同部位运动损伤修复重建的研究进展进行总结。结果 镁与镁合金材料在机械性能、生物安全性和促腱-骨界面愈合能力方面具有优势,目前有关镁与镁合金植入物修复重建运动相关损伤的临床前研究也取得了较好结果,但是其成功临床转化还需解决机械强度和降解行为问题,合金化和表面处理是可行的解决方案。结论 镁及镁合金植入物应用于运动损伤修复重建有望实现临床转化,后续应优化其机械强度和降解行为,开展更大规模的生物安全性测试和开发新型含镁植入物是未来研究方向。Objective To review the research progress of magnesium and magnesium alloy implants in the repair and reconstruction of sports injury.Methods Relevant literature of magnesium and magnesium alloys for sports injury repair and reconstruction was extensively reviewed.The characteristics of magnesium and its alloys and their applications in the repair and reconstruction of sports injuries across various anatomical sites were thoroughly discussed and summarized.Results Magnesium and magnesium alloys have advantages in mechanical properties,biosafety,and promoting tendon-bone interface healing.Many preclinical studies on magnesium and magnesium alloy implants for repairing and reconstructing sports injuries have yielded promising results.However,successful clinical translation still requires addressing issues related to mechanical strength and degradation behavior,where alloying and surface treatments offer feasible solutions.Conclusion The clinical translation of magnesium and magnesium alloy implants for repairing and reconstructing sports injuries holds promise.Subsequent efforts should focus on optimizing the mechanical strength and degradation behavior of magnesium and magnesium alloy implants.Conducting larger-scale biocompatibility testing and developing novel magnesium-containing implants represent new directions for future research.

关 键 词：镁 镁合金 生物可降解植入物 运动医学 修复重建 

分 类 号：G804.2[文化科学—运动人体科学] R318.08[文化科学—体育学] R87[医药卫生—生物医学工程]