西藏阿里西部地区成年藏族居民高同型半胱氨酸血症患病现况及影响因素分析  

Analysis on the prevalence and influencing factors of hyperhomocysteine mia among adult Tibetan residents in the west of Xizang Ali

作　　者：丁康致 张玉飞 王鹏 贾群娣 次仁央宗[1] 熊海 DING Kang-zhi;ZHANG Yu-fei;WANG Peng;JIA Qun-di;CIREN Yang-zong;XIONG Hai(Xizang University School of Medicine,Lhasa,Xizang 850000,China)

机构地区：[1]西藏大学医学院,西藏拉萨850000

出　　处：《现代预防医学》2024年第5期776-780,787,共6页Modern Preventive Medicine

基　　金：中央财政支持地方高校改革发展专项资金(00060585,00060695/051);阿里科技计划项目(ALKJ-BJCZ-2019-02)。

摘　　要：目的了解西藏阿里西部地区藏族居民高同型半胱氨酸血症患病现状及影响因素。方法采用多阶段整群随机抽样方法,在西藏阿里西部地区随机抽取藏族居民进行健康体检、问卷调查,收集血常规及生化指标。通过χ^(2)检验和多因素logistic回归分析该地区居民高同型半胱氨酸血症的患病情况及影响因素。结果共调查1362名西藏阿里西部地区藏族居民,研究结果显示高同型半胱氨酸血症患者为1044名,患病率76.7%,男性患病率为84.8%,高于女性的71.5%。吸烟(OR=1.988,95%CI:1.076~3.675)、贫困户(OR=1.775,95%CI:1.204~2.540)、高尿酸血症(OR=3.416,95%CI:2.494~4.679)、高胆固醇血症(OR=4.051,95%CI:2.811~5.838)、高甘油三酯血症(OR=2.589,95%CI:1.765~3.798)为高同型半胱氨酸血症患病危险因素,女性(OR=0.538,95%CI:0.384~0.752)、农牧区(OR=0.312,95%CI:0.156~0.625)为保护因素。结论西藏阿里西部地区高同型半胱氨酸血症患病率较高,性别、居住地、吸烟、贫困户是高同型半胱氨酸血症患病的影响因素。高同型半胱氨酸血症与高尿酸血症、高胆固醇血症、高甘油三酯血症等疾病显著相关。Objective To investigate the prevalence and influencing factors of hyperhomocysteinemia among Tibetan residents in the west of Xizang Ali.Methods By using the method of multi-stage cluster random sampling,Tibetan residents were randomly selected from the western area of Xizang Ali for physical examination and questionnaire survey,and blood routine and biochemical indexes were collected.The prevalence and influencing factors of hyperhomocysteinemia in this area were analyzed by chi-square test and multivariate logistic regression.Results A total of 1362 Tibetan residents in the western region of Xizang Ali were investigated.The results showed that there were 1044 patients with hyperhomocysteinemia,with a prevalence rate of 76.7%.The prevalence rate of males(84.8%)was higher than that of females(71.5%).Smoking(OR=1.988,95%Cl:1.076-3.675),poor household(OR=1.775,95%CI:1.204-2.540),hyperuricemia(OR=3.416,95%CI:2.494-4.679),hypercholesterolemia(OR=4.051,95%Cl:2.811-5.838),and hypertriglyceridemia(OR=2.589,95%Cl:1.765-3.798)were risk factors of hyperhomocysteinemia.Female(OR=0.538,95%Cl:0.384-0.752)and agricultural and pastoral areas(OR=0.312,95%Cl:0.156-0.625)were protective factors.Conclusion The prevalence rate of hyperhomocysteinemia is high in the western region of Xizang Ali.Sex,residence,smoking,and poor households are the influencing factors of hyperhomocysteinemia.Hyperhomocysteinemia is significantly associated with hyperuricemia,hypercholesterolemia,hypertriglyceridemia,and other diseases.

关 键 词：西藏阿里西部地区 藏族 高同型半胱氨酸血症 影响因素 

分 类 号：R544.1[医药卫生—心血管疾病]