保肾排石膏联合体外冲击波碎石术治疗下焦湿热型输尿管结石的效果  

Effect of Baoshen Paishi Plaster combined with extracorporeal shock wave lithotripsy in the treatment of ureteral calculi of lower-Jiao damp-heat syndrome and its effect on inflammatory factors and renal function

作　　者：刘永存[1] 苑士利 侯书恒[3] Liu Yongcun;Yuan Shili;Hou Shuheng(Department of Surgery,the Hospital of Traditional Chinese Medicine in Shijiazhuang,Shijiazhuang 050051,China;Department of Proctology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,China;Department of Emergency,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,China)

机构地区：[1]石家庄市中医院外科,石家庄050051 [2]石家庄市中医院肛肠科,石家庄050051 [3]石家庄市中医院急诊科,石家庄050051

出　　处：《国际泌尿系统杂志》2024年第2期193-197,共5页International Journal of Urology and Nephrology

基　　金：河北省中医药管理局科研计划项目(2021249)。

摘　　要：目的观察保肾排石膏联合体外冲击波碎石术治疗下焦湿热型输尿管结石的效果及其对炎症因子、肾功能的影响。方法选取2020年10月至2022年8月在本院就诊的128例下焦湿热型输尿管结石患者,根据不同治疗方法将患者分为观察组和对照组,每组64例。观察组给予保肾排石膏联合体外冲击波碎石术治疗,对照组仅给予体外冲击波碎石术治疗。比较两组患者的临床疗效、临床症状缓解时间、治疗前及治疗14 d后的炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、高敏C反应蛋白(hs-CRP)]水平,治疗前及治疗14 d后的肾功能指标[血清肌酐(Scr)、尿素氮(BUN)水平]、治疗期间不良反应及术后并发症情况。结果观察组治疗后的总有效率为93.75%(60/64),高于对照组的78.13%(50/64)(P<0.05)。观察组的血尿消失时间、腰痛缓解时间、排尿痛缓解时间均短于对照组(均P<0.001)。治疗后两组IL-6、TNF-α、hs-CRP水平均较治疗前降低,且观察组低于对照组(均P<0.001)。治疗后两组Scr、BUN水平均较治疗前降低,且观察组低于对照组(均P<0.001)。治疗期间两组无明显不良反应及术后并发症发生。结论保肾排石膏联合体外冲击波碎石术治疗下焦湿热型输尿管结石可提高疗效,改善患者症状,抑制机体炎症反应,提高肾功能,且安全性良好。Objective To observe the effect of Baoshen Paishi Plaster combined with extracorporeal shock wave lithotripsy in the treatment of lower-Jiao damp-heat ureteral calculi and its influence on inflammatory factors and renal function.Methods From October 2020 to August 2022,128 patients with lower-Jiao damp-heat ureteral calculi in our hospital were selected.According to different treatment methods,they were equally divided into observation group and control group,with 64 case in each group.The observation group was treated with Baoshen Paishi Plaster combined with extracorporeal shock wave lithotripsy,and the control group was only treated with extracorporeal shock wave lithotripsy.The clinical efficacy,remission time of clinical symptoms,inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and high sensitivity C-reactive protein(hs-CRP)]before and 14 days after treatment were compared between the two groups,renal function indexes,serum creatinine(Scr),urea nitrogen(BUN)levels before and 14 days after treatment,as well as adverse reactions and postoperative complications during treatment.Results The total effective rate in observation group was 93.75%(60/64),which was higher than 78.13%(50/64)in control group(P<0.05).The disappearance time of hematuria,the relief time of low back pain and the relief time of micturition pain in observation group were shorter than those in control group(all P<0.001).The levels of IL-6,TNF-αand hs-CRP after treatment in observation group were lower than those in control group(all P<0.001).After treatment,the levels of Scr and BUN in observation group were lower than those in control group(all P<0.001).There were no obvious adverse reactions and postoperative complications in two groups.Conclusions The treatment of ureteral calculi of lower-Jiao damp-heat syndrome with Baoshen Paishi Plaster combined with extracorporeal shock wave lithotripsy can improve the curative effect,improve the symptoms of patients,inhibit the inflammatory reaction and improve the renal funct

关 键 词：输尿管结石 体外冲击波疗法 保肾排石膏 肾功能 

分 类 号：R699.4[医药卫生—泌尿科学]