Hybridization chain reaction-based DNA nanomaterials for biosensing,bioimaging and therapeutics  

作　　者：Zhaoyue Lv Mengxue Huang Peiran Li Mengdi Xu Chi Yao Dayong Yang 

机构地区：[1]Frontiers Science Center for Synthetic Biology,Key Laboratory of Systems Bioengineering (MOE),Institute of Biomolecular and Biomedical Engineering,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China [2]Zhejiang Institute of Tianjin University,Ningbo 315201,China

出　　处：《Chinese Chemical Letters》2024年第2期223-231,共9页中国化学快报（英文版）

基　　金：supported in part by National Natural Science Foundation of China(Nos.22225505,22174097).

摘　　要：DNA nanomaterials hold great promise in biomedical fields due to its excellent sequence programmability,molecular recognition ability and biocompatibility.Hybridization chain reaction(HCR)is a simple and efficient isothermal enzyme-free amplification strategy of DNA,generating nicked double helices with repeated units.Through the design of HCR hairpins,multiple nanomaterials with desired functions are assembled by DNA,exhibiting great potential in biomedical applications.Herein,the recent progress of HCR-based DNA nanomaterials for biosensing,bioimaging and therapeutics are summarized.Representative works are exemplified to demonstrate how HCR-based DNA nanomaterials are designed and constructed.The challenges and prospects of the development of HCR-based DNA nanomaterials are discussed.We envision that rationally designing HCR-based DNA nanomaterials will facilitate the development of biomedical applications.

关 键 词：DNA nanotechnology Hybridization chain reaction DNA nanomaterials BIOSENSING BIOIMAGING Therapeutics 

分 类 号：TB383.1[一般工业技术—材料科学与工程] Q503[生物学—生物化学]