Free amino group-directed C(sp^(2))-H arylation ofα-amino-β-aryl esters by palladium catalysis  

作　　者：Yue Gao Yu Du Weiping Su 

机构地区：[1]State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,China [2]Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China,Fuzhou 350108,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Chemical Letters》2024年第2期358-360,共3页中国化学快报（英文版）

基　　金：supported by the National Key Research and Development Program of China(No.2018YFA0704502);the National Natural Science Foundation of China(Nos.21871261,21931011);Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China(No.2021ZZ105).

摘　　要：Native amino-directed palladium-catalyzed C(sp^(3))-H activation/functionalization has been developed for modification ofα-amino acids and peptides.Herein a palladium(Ⅱ)-catalyzed C(sp^(2))-H arylation ofα-amino-β-aryl esters has been disclosed,using the native amino as the directing group.A variety of chiralα-amino-β-aryl esters can be functionalized to give the corresponding ortho-substituted mono-and di-arylated products.

关 键 词：Native amino-directed Palladium catalyst C(sp^(2))-H arylation α-Amino-β-aryl ester Chiralα-amino acid 

分 类 号：O621.251[理学—有机化学]