Photo-induced 1,2-aryl migration of 2-chloro-1-arylpropanone under batch and flow conditions:Rapid,scalable and sustainable approach to 2-arylpropionic acids  

作　　者：Qiao Li Minjie Liu Meifen Jiang Li Wan Yingtang Ning Fen-Er Chen 

机构地区：[1]College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,China [2]Engineering Center of Catalysis and Synthesis for Chiral Molecules,Fudan University,Shanghai 200433,China [3]Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs,Shanghai 200433,China [4]Institute of Pharmaceutical Science and Technology,Zhejiang University of Technology,Hangzhou 310014,China

出　　处：《Chinese Chemical Letters》2024年第2期366-369,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(No.22077018)is gratefully acknowledged.

摘　　要：We report the photo-mediated 1,2-aryl migration of 2‑chloro-1-arylpropanones to 2-arylpropionic acids using HCOONa as an acid scavenger.This pragmatically focused study obviates the multiple-step sequence in the industrially employed,ZnO-promoted rearrangement strategy,and offers rapid access to various 2-arylpropionic acids under environmentally friendly conditions.Furthermore,the successful transfer of this batch photochemistry to a continuous flow platform led to improved scalability and enabled the gram-scale synthesis of loxoprofen.

关 键 词：Green chemistry Flow chemistry 2-Arylpropionic acids Photo-Favorskii reaction 

分 类 号：TQ460.3[化学工程—制药化工]