补中益气汤联合小柴胡汤在脾肺气虚型肺结节中的应用  

Buzhong Yiqi Decoction Combined with Xiaochaihu Decoction in the Treatment of Pulmonary Nodules of Qi Deficiency of Spleen and Lung Type

作　　者：宗飞 王健[2] 张而兰 ZONG Fei;WANG Jian;ZHANG Erlan(Department of Traditional Chinese Medicine,Xiamen Hospital of Traditional Chinese Medicine,Fujian Province,Xiamen 361009,China;Department of Traditional Chinese Medicine,Cangzhou Hospital of Integrated Traditional and Western Medicine,Hebei Province,Cangzhou 061001,China;Department of Respiratory Medicine,Xiamen Hospital of Traditional Chinese Medicine,Fujian Province,Xiamen 361009,China)

机构地区：[1]厦门市中医院中医内科,福建厦门361009 [2]河北省沧州中西医结合医院中医内科,河北沧州061001 [3]厦门市中医院呼吸科,福建厦门361009

出　　处：《光明中医》2024年第6期1136-1139,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

摘　　要：目的研究补中益气汤联合小柴胡汤用于脾肺气虚型肺结节的临床价值。方法选取脾肺气虚型肺结节患者90例,采用随机对照方法分为观察组(补中益气汤联合小柴胡汤治疗)及对照组(安慰剂治疗),每组45例。比较2组患者临床疗效。结果2组患者治疗前肺结节最大径、炎症因子水平、miR-200b及miR-200c差异无统计学意义。观察组治疗3个月后肺结节最大径、炎症因子水平均低于对照组(均P<0.05),miR-200b及miR-200c均高于对照组(均P<0.05)。2组患者均无明显并发症发生。结论补中益气汤联合小柴胡汤可降低脾肺气虚型肺结节最大径、炎症因子水平,提高miR-200b及miR-200c,疗效好且无明显不良反应。Objective To study the clinical value of Buzhong Yiqi decoction combined with Xiaochaihu decoction in the treatment of pulmonary nodules of qi deficiency of spleen and lung type.Methods A total of 90 patients with pulmonary nodules of qi deficiency of spleen and lung type were selected.Randomized control method was used to divide the patients into observation group(Buzhong Yiqi decoction combined with Xiaochaihu decoction)and control group(placebo treatment),with 45 cases in each group.The clinical efficacy of the two groups was compared.Results There were no significant differences in the maximum diameter of pulmonary nodules,levels of inflammatory factors,miR-200b and miR-200c between the two groups before treatment.After 3 months of treatment,the maximum diameter of pulmonary nodules and the levels of inflammatory factors in the observation group were lower than those in the control group(P<0.05),and the miR-200b and miR-200c were higher than those in the control group(P<0.05).No significant complications occurred in both groups.Conclusion Buzhong Yiqi decoction combined with Xiaochaihu decoction can reduce the maximum diameter of pulmonary nodules of spleen-lung qi deficiency type,the level of inflammatory factors,and increase miR-200b and miR-200c,with high curative effect and no obvious adverse reactions.

关 键 词：肺积 肺结节 脾肺气虚证 补中益气汤 小柴胡汤 经方 

分 类 号：R259[医药卫生—中西医结合]