两种用药方案治疗宫颈炎伴HR-HPV感染的实效性随机对照试验  

Randomized controlled trial on the effectiveness of two drug regimens in the treatment of cervicitis with HR-HPV infection

作　　者：缪敏君 王建霞 徐璟 MIAO Minjun;WANG Jianxia;XU Jing(Gynecology and Obstetrics Department,Jiangyin Lingang Hospital,Jiangyin 214443,China)

机构地区：[1]江阴临港医院妇产科,江苏江阴214443

出　　处：《临床医学研究与实践》2024年第9期43-46,共4页Clinical Research and Practice

基　　金：江阴市卫生健康委科研项目(No.G202109)。

摘　　要：目的探讨重组人干扰素α2b阴道泡腾片与聚甲酚磺醛溶液联合保妇康栓治疗宫颈炎伴高危型人乳头瘤病毒(HR-HPV)感染的实际效果。方法将2022年1月至2023年9月江阴临港医院收治的80例宫颈炎伴HR-HPV感染患者随机分为A组和B组,各40例。A组给予重组人干扰素α2b阴道泡腾片治疗,B组给予聚甲酚磺醛溶液联合保妇康栓治疗。比较两组的治疗效果。结果B组的宫颈炎治疗总有效率高于A组(P<0.05)。治疗后,B组的HR-HPV负荷量低于A组(P<0.05);B组的HR-HPV转阴率高于A组(P<0.05)。治疗后,B组的白细胞介素-1β(IL-1β)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)水平低于A组(P<0.05)。治疗后,B组的CD4+高于A组,CD8+低于A组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论相比于重组人干扰素α2b阴道泡腾片,聚甲酚磺醛溶液联合保妇康栓治疗宫颈炎伴HR-HPV感染实际效果更佳,且更为安全可靠。Objective To investigate the practical effect of recombinant human interferonα2b vaginal effervescent tablets and policresulen solution combined with Baofukang suppository in the treatment of cervicitis with high-risk human papilloma virus(HR-HPV)infection.Methods A total of 80 patients with cervicitis with HR-HPV infection admitted in Jiangyin Lingang Hospital from January 2022 to September 2023 were randomly divided into group A and group B,with 40 cases in each group.The group A was treated with recombinant human interferonα2b vaginal effervescent tablets,and the group B was treated with policresulen solution combined with Baofukang suppository.The therapeutic effects of the two groups were compared.Results The total effective rate of cervicitis treatment in the group B was higher than that in the group A(P<0.05).After treatment,the HR-HPV load of the group B was lower than that of the group A(P<0.05);the negative conversion rate of HR-HPV in the group B was higher than that in the group A(P<0.05).After treatment,the levels of interleukin-1β(IL-1β),interleukin-4(IL-4)and interleukin-6(IL-6)in the group B were lower than those of the group A(P<0.05).After treatment,CD4+in the group B was higher than that in the group A,and CD8+was lower than that in the group A(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared with recombinant human interferonα2b vaginal effervescent tablets,policresulen solution combined with Baofukang suppository is more effective in the treatment of cervicitis with HR-HPV infection,and more safe and reliable.

关 键 词：宫颈炎 高危型人乳头瘤病毒 聚甲酚磺醛溶液 保妇康栓 

分 类 号：R711.32[医药卫生—妇产科学]