麻杏石甘汤对风热闭肺证肺炎支原体肺炎患儿血清TLR2、TLR4和Th1/Th2免疫平衡的影响  

Effect of Maxing Shigan Decoction on Serum TLR2,TLR4,and Th1/Th2Immune Balance in Children with Mycoplasma Pneumoniae Pneumonia of Wind Heat Closed Lung Syndrome

作　　者：马晓婧 刘玉清[2] 罗雨薇 罗骏 杨嘉明 史文丽[3,4] MA Xiao-jing;LIU Yu-qing;LUO Yu-wei;LUO Jun;YANG Jia-ming;SHI Wen-li(The First Clinical Medical College of Bejing University of Traditional Chinese Medicine,Bejing,100029,China;Department of Pediatrics,Dongzhimen Hospital of Bejing University of Traditional Chinese Medicine,Beijing,100700,China;School of Pediatric Medicine,Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,450046,China;Department of Pediatrics,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,450000,China)

机构地区：[1]北京中医药大学第一临床医学院,北京100029 [2]北京中医药大学东直门医院儿科,北京100700 [3]河南中医药大学儿科医学院,河南郑州450046 [4]河南中医药大学第一附属医院儿科,河南郑州450000

出　　处：《现代生物医学进展》2023年第24期4647-4650,4705,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81904252);北京中医药大学一流学科建设中医儿科学科项目(90070161020004)。

摘　　要：目的:探讨麻杏石甘汤对风热闭肺证肺炎支原体肺炎(MPP)患儿血清Toll样受体(TLR)2、TLR4和辅助性T细胞(Th)1/Th2免疫平衡的影响。方法:按照随机数字表法将北京中医药大学东直门医院2021年1月到2023年1月收治的100例MPP患儿分为联合组(常规西医治疗结合麻杏石甘汤治疗,50例)和对照组(常规西医治疗,50例)。对比两组中医证候积分、潮气呼吸肺功能指标、TLR2、TLR4和Th1/Th2免疫平衡指标变化情况。结果:治疗14 d后,联合组发热恶风、微有汗出、咳嗽、口渴欲饮、呼吸急促、痰稠色黄、咽红评分低于对照组(P<0.05)。治疗14 d后,联合组潮气量(TV)、吸气时间与呼气时间之比(I/E)、达峰容积比(VPEF/VE)高于对照组,呼吸频率(RR)低于对照组(P<0.05)。治疗14 d后,联合组TLR2、TLR4低于对照组(P<0.05)。治疗14 d后,联合组干扰素γ(IFN-γ)、IFN-γ/白细胞介素-4(IL-4)低于对照组,IL-4高于对照组(P<0.05)。结论:麻杏石甘汤治疗风热闭肺证MPP患儿,可促进临床症状改善,同时还可改善患儿肺功能和免疫功能,调节血清TLR2、TLR4水平。Objective:To explore the effect of Maxing Shigan decoction on serum Toll like receptor(TLR)2,TLR4,and helper T cell(Th)1/Th2 immune balance in children with mycoplasma pneumoniae pneumonia(MPP)of wind heat closed lung syndrome.Methods:100 children with MPP who were admitted to Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine from January 2021 to January 2023 were divided into combined group(treated with conventional western medicine combined with Maxing Shigan decoction,50 cases)and control group(treated with conventional western medicine,50 cases)according to the random number table method.The changes in traditional Chinese medicine syndrome scores,tidal breathing and lung function indicators,TLR2,TLR4,and Th1/Th2 immune balance indicators between two groups were compared.Results:14 d after treatment,the scores of fever and aversion to wind,slight sweating,cough,thirsty and eager to drink,tachypnea,phlegm thick and yellow in color,pharyngeal redness in combined group were lower than those in control group(P<0.05).14 d after treatment,the tidal volume(TV),inspiratory time to expiratory time ratio(I/E),and the expiratory volume at peak tidal expiratory flow and total expiratory volume ratio(VPEF/VE)in combined group were higher than those in control group,and respiratory rate(RR)was lower than that in control group(P<0.05).14 d after treatment,the TLR2 and TLR4 in combined group were lower than those in control group(P<0.05).14 d after treatment,the interferonγ(IFN-γ)and IFN-γ/interleukin-4(IL-4)in combined group were lower than those in control group,and IL-4 was higher than that in control group(P<0.05).Conclusion:Maxing Shigan decoction in the treatment in children with MPP of wind heat closed lung syndrome,which can promote the improvement of clinical symptoms,which can also improve lung function and immune function in children at the same time,regulate the serum TLR2,TLR4 levels.

关 键 词：麻杏石甘汤 风热闭肺证 肺炎支原体肺炎 TOLL样受体2 TOLL样受体4 Th1/Th2免疫平衡 

分 类 号：R563.15[医药卫生—呼吸系统]