祛毒汤联合红光照射治疗促进湿热下注型低位单纯性肛瘘患者术后创面愈合的临床研究  

Clinical Study on Qudu Decoction Combined with Red Light Irradiation in Promoting Postoperative Wound Healing in Patients with Low Simple Anal Fistula of Damp-Heat Pouring Downward Type

作　　者：陈娟 单祖奇 李永豪 曹鑫 赵伟 CHEN Juan;SHAN Zu-qi;LI Yong-hao;CAO Xin;ZHAO Wei(Department of Anorectal,Xi'an Traditional Chinese Medicine Hospital,Xian,Shaanxi,710021,China;Department of Anorectal,Xian Lintong District Traditional Chinese Medicine Hospital,Xi'an,Shaanxi,710699,China;The First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi,712046,China)

机构地区：[1]西安市中医医院肛肠科,陕西西安710021 [2]西安市临潼区中医院肛肠科,陕西西安710699 [3]陕西中医药大学第一临床医学院,陕西咸阳712046

出　　处：《现代生物医学进展》2023年第24期4736-4739,4764,共5页Progress in Modern Biomedicine

基　　金：陕西省科学技术厅科技攻关项目(2021SF-403)。

摘　　要：目的:探讨祛毒汤联合红光照射治疗促进湿热下注型低位单纯性肛瘘患者术后创面愈合的临床疗效。方法:采用随机数字表法将西安市中医医院肛肠科2019年12月至2022年12月期间收治的116例湿热下注型低位单纯性肛瘘患者分为观察组(58例,红光照射、祛毒汤熏洗、常规治疗)和对照组(58例,红光照射、常规治疗)。对比两组临床疗效、创面愈合情况、血清炎症因子、血清生长因子变化情况。结果:与对照组相比,观察组创面愈合率更高,创面愈合时间更短,临床总有效率更高(P<0.05)。与对照组治疗后相比,观察组同时间点视觉模拟评分法(VAS)评分、创面渗出评分、创面肉芽生长情况评分更低,超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)更低,碱性成纤维细胞生长因子(bFGF)、表皮生长因子(EGF)、转化生长因子β(TGF-β)更高(P<0.05)。结论:祛毒汤联合红光照射治疗可促进湿热下注型低位单纯性肛瘘患者术后创面愈合,可调节炎症因子和生长因子水平。Objective:To investigate the clinical efficacy of qudu decoction combined with red light irradiation in promoting postoperative wound healing in patients with low simple anal fistula of damp-heat pouring downward type.Methods:116 patients with low simple anal fistula of damp-heat pouring downward type who were admitted to Anorectal Department of Xi'an Hospital of Traditional Chinese Medicine from December 2019 to December 2022 were divided into observation group(58 cases,red light irradiation,fumigation and washing with qudu decoction,routine treatment)and control group(58 cases,red light irradiation,routine treatment)by random number table method.The clinical efficacy,wound healing,serum inflammatory factors and serum growth factors were compared between two groups.Results:Compared with control group,the wound healing rate in observation group was higher,the wound healing time was shorter,and the total clinical effective rate was higher(P<0.05).Compared with control group after treatment,the visual analogue scale(VAS)score,wound exudation score,wound granulation growth score,high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),and interleukin-6(IL-6)were lower in observation group at the same time point,and basic fibroblast growth factor(bFGF),epidermal growth factor(EGF),and transforming growth factorβ(TGF-β)were higher(P<0.05).Conclusion:Qudu decoction combine with red light irradiation can promote postoperative wound healing in patients with low simple anal fistula of damp-heat pouring downward type,and can regulate the levels of inflammatory factors and growth factors.

关 键 词：低位单纯性肛瘘 祛毒汤 红光照射 湿热下注型 创面愈合 

分 类 号：R657.16[医药卫生—外科学]