从LncRNA探讨糖尿病及并发症发病机制与中医药干预研究进展  

Exploring the pathogenesis of diabetes mellitus and its complications from LncRNA and the progress of Chinese medicine intervention research

作　　者：周吉 周伟秀 祝然然 王子晨(综述) 阴永辉[2] 王海燕(审校)[1] Zhou Ji;Zhou Weixiu;Zhu Ranran;Wang Zichen;Yin Yonghui;Wang Haiyan(Department of Endocrinology,Qingdao Eighth People's Hospital,Shandong Province,Qingdao 266121,China;不详)

机构地区：[1]山东省青岛市第八人民医院内分泌科,266121 [2]山东中医药大学附属医院内分泌科,济南250014 [3]济南市中西医结合医院内分泌科,271100

出　　处：《疑难病杂志》2024年第3期375-379,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然青年科学基金(81503572);山东省自然科学基金面上项目(ZR2021MH088)。

摘　　要：糖尿病是临床常见的慢性代谢性疾病,长链非编码RNA(LncRNA)在糖尿病及其并发症发生发展中发挥了重要作用,是目前研究的热点机制之一。文章对多种LncRNA通过介导炎性反应、氧化应激、自噬、纤维化、内质网应激、细胞增殖及凋亡、铁死亡等病理过程影响糖尿病及其并发症进展进行综述,总结目前单味中药及中成药通过调控LncRNA改善糖尿病及其并发症的研究进展,以期为中药新药研发提供新的作用靶点,为糖尿病及并发症防治提供思路。Diabetes mellitus is a common chronic metabolic disease in clinic,and long-chain non-coding RNAs(LncRNAs)play an important role in the occurrence and development of diabetes mellitus and its complications,and it is one of the hot mechanisms of the current research.In this article,we review the effects of various LncRNAs on the progression of diabetes mellitus and its complications by mediating pathological processes such as inflammatory response,oxidative stress,autophagy,fibrosis,endoplasmic reticulum stress,cell proliferation and apoptosis,and iron death,etc.We summarize the current progress of research on the improvement of diabetes mellitus and its complications through the modulation of LncRNAs by single-flavored traditional Chinese medicines(TCMs)and proprietary Chinese medicine(pCms)with the aim of providing new targets for the R&D of TCM new drugs and providing ideas for the prevention and treatment of diabetes mellitus and its complications.We hope to provide new targets for the research and development of new Chinese medicines and ideas for the prevention and treatment of diabetes mellitus and its complications.

关 键 词：糖尿病 糖尿病并发症 长链非编码RNA 中医药 机制 研究进展 

分 类 号：R587.1[医药卫生—内分泌]