基于IAMEF模式的药学服务对获得性免疫缺陷综合征抗逆转录病毒治疗干预效果  

Intervention Effect of Pharmaceutical Care Based on IAMEF Mode on Anti-Retroviral Therapy for Acquired Immunodeficiency Syndrome

作　　者：刘青青[1] 乔进[1] 赵彦 石禹[1] LIU Qingqing;QIAO Jin;ZHAO Yan;SHI Yu(Nantong Third Hospital Affiliated to Nantong University·Nantong Third People's Hospital·Nantong Infectious Disease Prevention and Control Hospital,Nantong,Jiangsu,China 226006)

机构地区：[1]南通大学附属南通第三医院·江苏省南通市第三人民医院·江苏省南通市传染病防治院,江苏南通226006

出　　处：《中国药业》2024年第6期16-19,共4页China Pharmaceuticals

基　　金：江苏省南通市青年医学重点人才项目[WR2017011]。

摘　　要：目的探讨基于IAMEF模式的药学服务对获得性免疫缺陷综合征(AIDS)患者抗逆转录病毒治疗(ART)的干预效果。方法选取医院感染免疫门诊2020年1月至2022年1月收治的接受ART的AIDS患者170例,按随机数字表法分为观察组和对照组,各85例。两组患者均予基本的药品保障供应及常规药学咨询服务,观察组患者加予基于信息收集-分析评估-制订计划-执行计划-跟踪随访(IAMEF)模式的药学服务,两组均干预10个月。比较干预前后患者的T淋巴细胞亚群水平、病毒载量、服药依从性及不良反应发生率。结果与对照组比较,观察组患者干预后的CD_(3)^(+)和CD_(4)^(+)水平及CD_(4)^(+)/CD_(8)^(+)均显著升高,病毒载量显著降低(P<0.05)。干预后,观察组患者服药依从性好的占比及Morisky用药依从性量表-8评分均显著高于对照组,且漏服药物、定时服药及遵医嘱剂量用药占比均显著优于对照组(P<0.05)。观察组患者不良反应发生率为17.65%,显著低于对照组的47.06%(P<0.05)。结论基于IAMEF模式的药学服务可改善AIDS患者的T淋巴细胞水平,降低病毒载量,提高服药依从性,降低不良反应发生率。Objective To investigate the intervention effect of pharmaceutical care based on the IAMEF mode on the anti-retroviral therapy(ART)in patients with acquired immunodeficiency syndrome(AIDS).Methods A total of 170 AIDS patients receiving ART in the infection and immunization clinic of the hospital from January 2020 to January 2022 were selected and divided into the observation group and the control group by the random number table method,with 85 cases in each group.The patients in the two groups were given basic drug supply and routine pharmaceutical consultation service,on this basis,the patients in the observation group were given pharmaceutical care based on the information gathering-analysis and evaluation-make plan-execution plan-follow up(IAMEF)mode.Both groups were intervened for 10 months.The T lymphocyte subset levels,viral load,medication adherence and incidence of adverse reactions in the two groups before and after intervention were compared.Results Compared with those in the control group,the CD_(3)^(+),CD_(4)^(+)levels and CD_(4)^(+)/CD_(8)^(+)after intervention in the observation group were significantly higher,and the viral load was significantly lower(P<0.05).After intervention,the proportion of patients with good medication adherence and the Morisky Medication Adherence Scale-8 score in the observation group were significantly higher than those in the control group,the proportions of patients missing medication,taking medicine regularly and following the prescribed dose were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 17.65%,which was significantly lower than 47.06%in the control group(P<0.05).Conclusion Pharmaceutical care based on the IAMEF mode can improve T lymphocyte levels,reduce viral load,improve medication adherence and reduce the incidence of adverse reactions in AIDS patients.

关 键 词：药学服务 IAMEF模式 获得性免疫缺陷综合征 抗逆转录病毒治疗 干预效果 

分 类 号：R95[医药卫生—药学]